Special Issue "Challenges in Process Analytical Technologies for Mammalian Cell Cultures"

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (31 May 2021).

Special Issue Editors

Dr. Laurent Dewasme
E-Mail Website
Guest Editor
Systems, Estimation, Control and Optimization Group (SECO), Faculty of Engineering, University of Mons, Mons, Belgium
Interests: bioprocess control and optimization; modeling of biological systems; parameter and state estimation applied to biological systems; machine learning; biomedical signal processing
Dr. Véronique Chotteau
E-Mail Website
Guest Editor
1. Cell Technology, Department of Industrial Biotechnology, KTH-Royal Institute of Technology in Stockholm, 10691 Stockholm, Sweden
2. AdBIOPRO, Competence Centre for Advanced BioProduction by Continuous Processing
Interests: bioprocess of established cell lines to produce biologics such as biopharmaceuticals and viral vectors; bioprocess of human stem cells; perfusion technology; mathematical modelling using metabolic flux analysis; purification by magnetic beads
Prof. Dr. Alain Vande Wouwer
E-Mail Website
Guest Editor
Automatic Control Laboratory, University of Mons, 31 Boulevard Dolez, 7000 Mons, Belgium
Interests: mathematical modeling; metabolic flux analysis; numerical simulation; identification; data-driven techniques; process control; model predictive control
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Special Issue Information

Dear Colleagues,

Among the challenges raised by the recent Industry 4.0 revolution, mathematical modelling plays a key role in supervisory control and data acquisition (SCADA) systems used in industrial processes. In the specific context of biopharmaceuticals, where Process Analytical Technologies (PAT) are nowadays recommended for manufacturing, bioprocess yield and repeatability improvements are conditioned by the availability of dynamic models.

Mammalian cell cultures are the source of most biopharmaceutical therapeutics (monoclonal antibodies (MAbs), vaccines, glycoproteins, viral vectors, etc.), and the application of mechanistic and data-driven model-based software solutions has proved to significantly improve process productivity. However, some problematics remain, related to the inherent uncertainty of biosystems. Optimization methods may therefore be model-based—with some robust tolerance to model uncertainties—or model-free, using a limited a priori knowledge of process operation and without considering a full dynamic system.

This Special Issue focuses on original concepts in PAT and process monitoring, ranging from the application of instrumentation based on hardware and software sensors to the use of data-driven or model-based approaches. The submitted papers should present numerical and experimental applications for mammalian/human cell culture processes.

Dr. Laurent Dewasme
Dr. Véronique Chotteau
Prof. Dr. Alain Vande Wouwer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mammalian cell culture modelling
  • Metabolic pathway analysis
  • Instrumentation
  • PAT
  • State estimation
  • Software sensors
  • Model predictive control
  • Adaptive control
  • Robust control
  • Real-time optimization

Published Papers

There is no accepted submissions to this special issue at this moment.
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