Challenges in Process Analytical Technologies for Mammalian Cell Cultures
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 439
Special Issue Editors
Interests: bioprocess control and optimization; modeling of biological systems; parameter and state estimation applied to biological systems; machine learning; biomedical signal processing
2. AdBIOPRO, Competence Centre for Advanced BioProduction by Continuous Processing
Interests: bioprocess of established cell lines to produce biologics such as biopharmaceuticals and viral vectors; bioprocess of human stem cells; perfusion technology; mathematical modelling using metabolic flux analysis; purification by magnetic beads
Interests: mathematical modeling; metabolic flux analysis; numerical simulation; identification; data-driven techniques; process control; model predictive control
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Special Issue Information
Dear Colleagues,
Among the challenges raised by the recent Industry 4.0 revolution, mathematical modelling plays a key role in supervisory control and data acquisition (SCADA) systems used in industrial processes. In the specific context of biopharmaceuticals, where Process Analytical Technologies (PAT) are nowadays recommended for manufacturing, bioprocess yield and repeatability improvements are conditioned by the availability of dynamic models.
Mammalian cell cultures are the source of most biopharmaceutical therapeutics (monoclonal antibodies (MAbs), vaccines, glycoproteins, viral vectors, etc.), and the application of mechanistic and data-driven model-based software solutions has proved to significantly improve process productivity. However, some problematics remain, related to the inherent uncertainty of biosystems. Optimization methods may therefore be model-based—with some robust tolerance to model uncertainties—or model-free, using a limited a priori knowledge of process operation and without considering a full dynamic system.
This Special Issue focuses on original concepts in PAT and process monitoring, ranging from the application of instrumentation based on hardware and software sensors to the use of data-driven or model-based approaches. The submitted papers should present numerical and experimental applications for mammalian/human cell culture processes.
Dr. Laurent Dewasme
Dr. Véronique Chotteau
Prof. Dr. Alain Vande Wouwer
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- Mammalian cell culture modelling
- Metabolic pathway analysis
- Instrumentation
- PAT
- State estimation
- Software sensors
- Model predictive control
- Adaptive control
- Robust control
- Real-time optimization
