Cell sheet engineering has become a popular approach in the last couple of decades, mainly because of the obvious need for the better delivery of stem cells that undergo cell death after delivery by injection.

However, recent advances in this field have expanded our understanding of the cells’ biology within these multilayered constructs enriched by native extracellular matrix. At the moment, we believe that cell sheet engineering has gone far beyond an approach for the delivery of stem cells to treat disease, and has laid ground for next-level tissue modeling for both applied and basic research.

For this Special Issue, we invite cell biologists, specialists in ex vivo models, and tissue engineering as well as researchers in regenerative medicine to contribute their original research, reviews, hypotheses, and letters to provide an insight into the new achievements and directions in this field.

The Issue’s scope is focused on the cell sheets from different types of cells, their properties, and applications, and will give favor to new applications in tissue modeling and basic research regarding mechanisms of morphogenesis, regeneration, or cellular self-organization.

However, potential contributions are not limited to the above-mentioned, and communications on decellularized materials from cell sheets or the application of cell sheet-derived secretome or vesicles will be considered.

We expect that review submissions will be either invited or presented as an abstract for editorial consideration before submission of full-text manuscript. Experimental studies can be submitted according to the authors’ initiative within the deadlines, and will undergo editorial evaluation with peer review according to the journal’s rules of manuscript processing.

Dr. Pavel Makarevich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Cell sheet
• Adult stem cells
• Tissue engineering
• Cell therapy
• Tissue models
• 3D models and cultures