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Bioengineering
Special Issues
Advanced Therapeutic Approaches for Musculoskeletal Tissue Regeneration
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Advanced Therapeutic Approaches for Musculoskeletal Tissue Regeneration

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 6301

Special Issue Editor

Dr. Jiabing Fan

E-Mail Website
Guest Editor
Pharmaceutical Sciences, University of Maryland, Eastern Shore, Princess Anne, MD 21853, USA
Interests: design and fabricate biomimetic polymer systems for tissue regeneration and drug delivery applications, particularly focusing on orthobiologics, customized scaffolds, injectable hydrogels, and controlled release

Special Issue Information

Dear Colleagues,

The overall goal of this Special Issue is to present a broad review of recent advances in developing novel therapeutic approaches for musculoskeletal tissue regeneration, especially under challenging disease conditions such as chronic osteoporotic disorders. The human musculoskeletal system offers structural and mechanical support to our body and protects the delicate internal organs. Musculoskeletal disorders are increasingly prevalent, particularly in the aging population, posing significant health issues with increasing medical and socioeconomic burdens. Notably, the prevalence of age-related chronic degenerative diseases leads to extreme clinical challenges in the treatment of musculoskeletal injury. Although the conventional therapeutic modalities including auto/allografts have been conducted in musculoskeletal tissue regeneration, they are significantly restricted by availability, disease transmission and reproducibility. Tissue engineering involved in stem cells, growth factors and biomaterials represents a promising strategy to restore musculoskeletal tissue structures and functions. In the past few decades, the tissue engineering-based approach has evolved rapidly due to significant advances in the underlying mechanisms of stem cell and tissue development, biomaterial fabrication, animal disease models and multidisciplinary integration.

This Special Issue on “Advanced Therapeutic Approaches for Musculoskeletal Tissue Regeneration” is open for original papers and reviews that are dedicated to the development of novel therapeutic approaches for musculoskeletal tissue repair and regeneration. 

The topics and themes of this unique collection will include, but are not limited to, the following:

  • Novel molecular mechanism studies on the lineage commitment of mesenchymal stem cells;
  • The creation of novel biomaterials for cell, gene/drug and growth factor carriers;
  • Novel animal disease models created for the efficient evaluation of pre-clinical treatment;
  • Advanced application of mesenchymal stem cell (MSC)-mediated treatment;
  • The application of a cell-free approach such as MSC-derived exosomes for musculoskeletal tissue regeneration;
  • New therapeutic strategies developed for tissue regeneration under chronic degenerative disease conditions;
  • Developing a translational therapeutic approach for potential clinical application.

Dr. Jiabing Fan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • exosomes
  • growth factor
  • biomaterials
  • drug/gene delivery
  • molecular therapy
  • gene therapy
  • tissue engineering
  • animal disease models
  • clinical application

Published Papers (2 papers)

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Review

15 pages, 8732 KiB  
Review
Impact of Microenvironmental Changes during Degeneration on Intervertebral Disc Progenitor Cells: A Comparison with Mesenchymal Stem Cells
by Feng-Juan Lyu
Bioengineering 2022, 9(4), 148; https://0-doi-org.brum.beds.ac.uk/10.3390/bioengineering9040148 - 01 Apr 2022
Cited by 10 | Viewed by 2268
Abstract
Intervertebral disc (IVD) degeneration occurs with natural ageing and is linked to low back pain, a common disease. As an avascular tissue, the microenvironment inside the IVD is harsh. During degeneration, the condition becomes even more compromised, presenting a significant challenge to the [...] Read more.
Intervertebral disc (IVD) degeneration occurs with natural ageing and is linked to low back pain, a common disease. As an avascular tissue, the microenvironment inside the IVD is harsh. During degeneration, the condition becomes even more compromised, presenting a significant challenge to the survival and function of the resident cells, as well as to any regeneration attempts using cell implantation. Mesenchymal stem cells (MSCs) have been proposed as a candidate stem cell tool for IVD regeneration. Recently, endogenous IVD progenitor cells have been identified inside the IVD, highlighting their potential for self-repair. IVD progenitor cells have properties similar to MSCs, with minor differences in potency and surface marker expression. Currently, it is unclear how IVD progenitor cells react to microenvironmental factors and in what ways they possibly behave differently to MSCs. Here, we first summarized the microenvironmental factors presented in the IVD and their changes during degeneration. Then, we analyzed the available studies on the responses of IVD progenitor cells and MSCs to these factors, and made comparisons between these two types of cells, when possible, in an attempt to achieve a clear understanding of the characteristics of IVD progenitor cells when compared to MSCs; as well as, to provide possible clues to cell fate after implantation, which may facilitate future manipulation and design of IVD regeneration studies. Full article
(This article belongs to the Special Issue Advanced Therapeutic Approaches for Musculoskeletal Tissue Regeneration)
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21 pages, 645 KiB  
Review
Effectiveness of Platform-Based Robot-Assisted Rehabilitation for Musculoskeletal or Neurologic Injuries: A Systematic Review
by Anil Babu Payedimarri, Matteo Ratti, Riccardo Rescinito, Kris Vanhaecht and Massimiliano Panella
Bioengineering 2022, 9(4), 129; https://0-doi-org.brum.beds.ac.uk/10.3390/bioengineering9040129 - 22 Mar 2022
Cited by 19 | Viewed by 3715
Abstract
During the last ten years the use of robotic-assisted rehabilitation has increased significantly. Compared with traditional care, robotic rehabilitation has several potential advantages. Platform-based robotic rehabilitation can help patients recover from musculoskeletal and neurological conditions. Evidence on how platform-based robotic technologies can positively [...] Read more.
During the last ten years the use of robotic-assisted rehabilitation has increased significantly. Compared with traditional care, robotic rehabilitation has several potential advantages. Platform-based robotic rehabilitation can help patients recover from musculoskeletal and neurological conditions. Evidence on how platform-based robotic technologies can positively impact on disability recovery is still lacking, and it is unclear which intervention is most effective in individual cases. This systematic review aims to evaluate the effectiveness of platform-based robotic rehabilitation for individuals with musculoskeletal or neurological injuries. Thirty-eight studies met the inclusion criteria and evaluated the efficacy of platform-based rehabilitation robots. Our findings showed that rehabilitation with platform-based robots produced some encouraging results. Among the platform-based robots studied, the VR-based Rutgers Ankle and the Hunova were found to be the most effective robots for the rehabilitation of patients with neurological conditions (stroke, spinal cord injury, Parkinson’s disease) and various musculoskeletal ankle injuries. Our results were drawn mainly from studies with low-level evidence, and we think that our conclusions should be taken with caution to some extent and that further studies are needed to better evaluate the effectiveness of platform-based robotic rehabilitation devices. Full article
(This article belongs to the Special Issue Advanced Therapeutic Approaches for Musculoskeletal Tissue Regeneration)
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