10th Anniversary of Biology: Cyclic Nucleotide Signaling

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3426

Special Issue Editor

Department of Biochemistry & Molecular Biology and Center for Lung Biology, Whiddon College of Medicine, University of South Alabama, Mobile, AL 36688, USA
Interests: cellular signaling; cAMP; cyclic nucleotide phosphodiesterases; PDE4; cystic fibrosis; Pseudomonas aeruginosa; lung infection/inflammation
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Special Issue Information

Dear Colleagues,

The year 2021 marks the 10th anniversary of Biology, a peer-reviewed open access journal on biological sciences. Biology has published more than 1200 papers from more than 8300 authors. We are grateful to every author, reviewer, and academic editor whose support has made us where we are today.

To mark this significant milestone, a Special Issue entitled “10th Anniversary of Biology: Cyclic Nucleotide Signaling” is being launched. Since their discovery in the 1970s, cyclic nucleotides have been shown to serve as critical signalling molecules across all branches of life. In procaryotes, cAMP plays vital roles in the regulation of virulence and catabolite repression, whereas in fungi, cyclic nucleotides are involved in the regulation of sexual development, differentiation, and response to stress. In vertebrates, cyclic nucleotides act as second messengers that transduce the action of a myriad of extracellular signals, ranging from hormones and neurotransmitters, to proton concentration or light, into the appropriate cellular responses, and thereby impact essentially all cellular and physiologic functions from the beginning of life (fertilization) to the end of life (cellular apoptosis and death). Despite major advances, much remains to be learned, as illustrated by the recent discovery of important roles for novel, non-canonical cyclic nucleotides (such as cUMP), or the discovery of novel cyclic nucleotide effector proteins (such as Popeye domain-containing proteins (POPDC)). Furthermore, we are just beginning to answer some of the major questions and enigmas in the field, such as how production of the same second messenger (e.g. cAMP) can accurately transduce the action of a multitude of extracellular signals that act on the same cell into the appropriate cellular responses.

This Special Issue welcomes original research, short communications, and review manuscripts broadly related to cyclic nucleotide signalling, ranging from historical perspectives to reports of recent advances, from basic mechanistic insights to novel critical functions in health and disease, and from the canonical cyclic nucleotides, cAMP and cGMP, to the more recently discovered non-canonical cyclic nucleotides.

Dr. Wito Richter
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cyclic nucleotide signaling
  • cAMP
  • cGMP
  • compartmentalization
  • cyclases
  • phosphodiesterases
  • PDE
  • effector proteins
  • physiologic and pathologic states
  • inhibitor/drug development

Published Papers (1 paper)

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Research

12 pages, 2257 KiB  
Article
Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa
by Kasidid Ruksakiet, Balázs Stercz, Gergő Tóth, Pongsiri Jaikumpun, Ilona Gróf, Roland Tengölics, Zsolt M. Lohinai, Péter Horváth, Mária A. Deli, Martin C. Steward, Orsolya Dobay and Ákos Zsembery
Biology 2021, 10(6), 519; https://0-doi-org.brum.beds.ac.uk/10.3390/biology10060519 - 10 Jun 2021
Cited by 1 | Viewed by 2885
Abstract
The formation of Pseudomonas aeruginosa biofilms in cystic fibrosis (CF) is one of the most common causes of morbidity and mortality in CF patients. Cyclic di-GMP and cyclic AMP are second messengers regulating the bacterial lifestyle transition in response to environmental signals. We [...] Read more.
The formation of Pseudomonas aeruginosa biofilms in cystic fibrosis (CF) is one of the most common causes of morbidity and mortality in CF patients. Cyclic di-GMP and cyclic AMP are second messengers regulating the bacterial lifestyle transition in response to environmental signals. We aimed to investigate the effects of extracellular pH and bicarbonate on intracellular c-di-GMP and cAMP levels, and on biofilm formation. P. aeruginosa was inoculated in a brain–heart infusion medium supplemented with 25 and 50 mM NaCl in ambient air (pH adjusted to 7.4 and 7.7 respectively), or with 25 and 50 mM NaHCO3 in 5% CO2 (pH 7.4 and 7.7). After 16 h incubation, c-di-GMP and cAMP were extracted and their concentrations determined. Biofilm formation was investigated using an xCelligence real-time cell analyzer and by crystal violet assay. Our results show that HCO3 exposure decreased c-di-GMP and increased cAMP levels in a dose-dependent manner. Biofilm formation was also reduced after 48 h exposure to HCO3. The reciprocal changes in second messenger concentrations were not influenced by changes in medium pH or osmolality. These findings indicate that HCO3 per se modulates the levels of c-di-GMP and cAMP, thereby inhibiting biofilm formation and promoting the planktonic lifestyle of the bacteria. Full article
(This article belongs to the Special Issue 10th Anniversary of Biology: Cyclic Nucleotide Signaling)
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