Journal Browser

► Journal Browser

Special Issue Editors

Special Issue Information

Dear Colleagues,

Calcium (Ca²⁺) signaling delivers the spatial and temporal signals necessary to control and regulate various cell types. In particular, cytosolic Ca²⁺ serves as a universal second messenger that not only regulates such processes as autophagy and apoptosis, but also influences cell division/growth and gene expression. Recent evidence suggests that abnormal Ca²⁺ signaling is a hallmark of many disorders, including: neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and Huntington’s disease; cardiac disease; schizophrenia and bipolar disorder; and lung infection and diseases such as cystic fibrosis and lung cancer.

This Special Issue welcomes submissions of original research articles, reviews and short communications focusing on Ca²⁺ signaling dysregulation and disease, in particular mechanisms underlying potential pathology and disease development, ranging from altered cell signaling and immune cell function to potential population-based studies.

Dr. Rob U. Onyenwoke
Guest Editor
Dr. Vijay Sivaraman
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

calcium (Ca²⁺) signaling
Transient Receptor Potential (TRP) channels
inositol trisphosphate receptor
pulmonary disease
neurodegenerative disease
Alzheimer’s disease
Parkinson’s disease
inflammatory response
autophagy
apoptosis

Published Papers (2 papers)

Download All Papers

Editorial

Jump to: Review

3 pages, 171 KiB

Open AccessEditorial

Calcium Signaling Derangement and Disease Development and Progression

by Vijay Sivaraman and Rob U. Onyenwoke

Biology 2021, 10(4), 291; https://0-doi-org.brum.beds.ac.uk/10.3390/biology10040291 - 02 Apr 2021

Cited by 3 | Viewed by 1540

Abstract

The importance of intracellular calcium (Ca²⁺) in regulating integral biological functions such as cell division, cell motility, autophagy, apoptosis and gene transcription through its capacity as a ubiquitous second messenger is clear [...] Full article

(This article belongs to the Special Issue Calcium Signaling Derangement and Disease Development and Progression)

Review

Jump to: Editorial

11 pages, 593 KiB

Open AccessFeature PaperReview

Calcium-Dependent Pulmonary Inflammation and Pharmacological Interventions and Mediators

by Jeffrey G. Shipman, Rob U. Onyenwoke and Vijay Sivaraman

Biology 2021, 10(10), 1053; https://0-doi-org.brum.beds.ac.uk/10.3390/biology10101053 - 16 Oct 2021

Cited by 4 | Viewed by 2026

Abstract

Pulmonary diseases present a significant burden worldwide and lead to severe morbidity and mortality. Lung inflammation caused by interactions with either viruses, bacteria or fungi is a prominent characteristic of many pulmonary diseases. Tobacco smoke and E-cig use (“vaping”) are considered major risk factors in the development of pulmonary disease as well as worsening disease prognosis. However, at present, relatively little is known about the mechanistic actions by which smoking and vaping may worsen the disease. One theory suggests that long-term vaping leads to Ca²⁺ signaling dysregulation. Ca²⁺ is an important secondary messenger in signal transduction. Cellular Ca²⁺ concentrations are mediated by a complex series of pumps, channels, transporters and exchangers that are responsible for triggering various intracellular processes such as cell death, proliferation and secretion. In this review, we provide a detailed understating of the complex series of components that mediate Ca²⁺ signaling and how their dysfunction may result in pulmonary disease. Furthermore, we summarize the recent literature investigating the negative effects of smoking and vaping on pulmonary disease, cell toxicity and Ca²⁺ signaling. Finally, we summarize Ca²⁺-mediated pharmacological interventions that could potentially lead to novel treatments for pulmonary diseases. Full article

(This article belongs to the Special Issue Calcium Signaling Derangement and Disease Development and Progression)

► Show Figures