Dear Colleagues and Fellow Researchers,

I would like to invite you to submit some of your outstanding work to this MDPI Special Edition on Immune Tolerance. The constant necessity of recognition of self-antigens and pathogens has a deep impact in our society. Tolerance is fundamental to immunity due to the continuous selection of higher antigen specificity. Lymphocyte education is critical to healthy humoral immunity, and a fail in self-tolerance is the hallmark for the development of auto-immunity. In addition to the well-studied impact of genetics, the pressure of surroundings presents unprecedented challenges to bench and clinical research in the field. Tolerance mechanisms have been widely described from animal models and genomic and proteomic studies. However, the impact of inflammation, infection, and cancer in breaking immune tolerance during defense, surveillance, and homeostasis remains unclear.

It is therefore relevant to discuss beyond antigen affinity and lymphocyte selection. Plasticity can be affected by immunopotentiators and suppressants, sugar metabolism can be correlated with bacterial symbiosis, and membrane neuro-immune molecules can fail to discriminate between senescence and on-going infection. Alternatively, on-going inflammation can yield long-distance cues inducing macrophage differentiation, affect controlled cell death, and control lipid signaling during resolution.

This Special Issue aims to encourage the submission of original research and review manuscripts focused in experimental and clinical work in the field of immune tolerance. Aiming to widen the horizon of the field, this title will approach classic and modern methodologies and focus on the roles of cellular communication and molecular regulation as a bridge between clinical manifestation and the development of auto-immunity.

Dr. Tiago Granja
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• tolerance
• immunity
• plasticity
• inflammation
• resolution
• differentiation
• symbiosis
• antigen affinity
• autoimmunity