Signalling Pathways and Disease

Dear Colleagues,

The complexity of multicellular organisms and the different cellular processes that are being orchestrated continuously in the background means that a multitude of signalling pathways must be functional for these processes to occur. From organ growth to such processes as varied as development, cellular proliferation, cell–cell adhesion, extracellular matrix signalling, mechanotransduction, polarity and apoptosis—all of these are fundamental processes required for the activation of key signalling pathways in order for the processes to fulfil their requirement. If these signalling pathways begin to dysfunction, it may result in a range of diseases, including cancer, neurodegeneration, and many other debilitating diseases. This Special Issue welcomes the submission of articles and reviews that cover a wide range of signalling pathways and how any disruption to these pathways can lead to disease. I hope that we will try to expand upon what is currently known in the signalling field in this Special Issue by looking at new cutting-edge findings that will hopefully shed some light on how signalling can control disease progression.

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• hippo signalling
• mechanotransduction
• YAP
• cancer
• polarity
• Rho GTPases
• signalling
• organ growth
• extracellular matrix
• integrins