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Biology
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The Role and Regulation of Autophagy in Cancer Cells
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The Role and Regulation of Autophagy in Cancer Cells

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".

Deadline for manuscript submissions: closed (14 February 2022) | Viewed by 3307

Special Issue Editors

Prof. Dr. Antonio Ieni

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Guest Editor
Department of Human Pathology of Adults and Developmental Age, Gaetano Barresi, University of Messina, Piazza Pugliatti, 1, 98122 Messina ME, Italy
Interests: metastasis; cell culture; cancer cells; cancer biology; immunohistochemistry; cancer diagnostics; cancer biomarkers; immunocytochemistry
Prof. Dr. Giovanni Tuccari

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Guest Editor
Dipartimento di Patologia Umana Dell’adulto e Dell’età Evolutiva Gaetano Barresi, Divisione di Anatomia Patologica, Università Degli Studi di Messina, 98125 Messina, Italy
Interests: autophagy; molecular biology; pathology; innate immunity; gastritis; Helicobacter pylori; neutrophils; mast cell
Special Issues, Collections and Topics in MDPI journals
Dr. Rosario Alberto Caruso

E-Mail Website
Guest Editor
Department of Human Pathology, University of Messina, 98123 Messina, Italy
Interests: ultrastructure; histology; pathology; histochemistry; immunohistochemistry; cytology
Dr. Rosario Caltabiano

E-Mail Website
Guest Editor
Department of Medical, Surgical and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95123 Catania, Italy
Interests: immunohistochemistry; dermatopathology; neuropathology; uveal melanoma; head and neck pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Autophagy plays a controversial role in cancer and its inhibition may be an effective therapeutic strategy in advanced cancer. A deeper understanding of autophagy within the tumor microenvironment can improve the development of novel inhibitors and clinical trial strategies. Challenges and opportunities remain in identifying the patients most likely to benefit from this approach.

Dear Colleagues,

Autophagy represents a multistep primary process for cells to degrade unnecessary proteins/damaged organelles and also to recycle cellular components. To date, the intriguing double role of autophagy in cancer remains still controversial. Under homeostatic conditions, autophagy is regarded as a tumor suppressor process, but recently it has been demonstrated that the dysregulation of autophagy can induce genomic instability in non-neoplastic cells and successively promote oncogenetic transformation. In addition, the upregulation of autophagy has been shown to enhance the survival ability of cancer cells in response to various micro-environmental stresses and different chemotherapeutic agents.

Therefore, further insights into the function of autophagy in neoplastic conditions are needed to identify new potential key autophagy targets to improve the development of therapeutic agents for cancer therapy.

This Special Issue entitled “The Role and Regulation of Autophagy in Cancer Cells” welcomes the submission of original and review papers covering the broad range of topics related to the biological and clinical relationship between autophagy and tumors.

Prof. Dr. Antonio Ieni
Prof. Dr. Giovanni Tuccari
Dr. Rosario Alberto Caruso
Prof. Dr. Rosario Caltabiano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Autophagy
  • cancer
  • chemotherapy
  • autophagy-related proteins
  • prognosis
  • survival.

Published Papers (1 paper)

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Research

12 pages, 2119 KiB  
Article
Gymnema sylvestre Extract Restores the Autophagic Pathway in Human Glioblastoma Cells U87Mg
by Rossella Rotondo, Salvatore Castaldo, Maria Antonietta Oliva and Antonietta Arcella
Biology 2021, 10(9), 870; https://0-doi-org.brum.beds.ac.uk/10.3390/biology10090870 - 04 Sep 2021
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Abstract
Glioblastoma is a brain tumour, characterised by recurrent or innate resistance to conventional chemoradiotherapy. Novel natural molecules and phyto-extracts have been proposed as adjuvants to sensitise the response to Temozolomide (TMZ). In this study, we investigated the effect of GS extract on human [...] Read more.
Glioblastoma is a brain tumour, characterised by recurrent or innate resistance to conventional chemoradiotherapy. Novel natural molecules and phyto-extracts have been proposed as adjuvants to sensitise the response to Temozolomide (TMZ). In this study, we investigated the effect of GS extract on human glioblastoma cells U87Mg. According to the IC50-values, GS extract displayed a significant cytotoxicity. This was confirmed by cell growth inhibition and alteration in metabolic activity evaluated by cell count and MTT assay. GS induced reduction in Pro-caspase 9, 3, but not PARP cleavage nor DNA fragmentation. Thus, in GS-induced cytotoxicity, cell death is not associated with apoptosis. In this context, short-term treatment of U87Mg cells with GS extract (1 mg/mL) reduced the phosphorylation levels of mTOR and of its downstream target P70 S6 kinase, highlighting the role of GS extract into autophagy induction. The activation of autophagic flux by GS extract was confirmed by Western blot analysis, which revealed the reduction in p62 and the concomitant increase in LC3B II/I ratio. Immunofluorescence evidenced the accumulation of LC3B puncta in U87Mg cells pretreated with autophagy inhibitor Bafilomycin A1. Furthermore, as main key regulators of type II programmed cell death, p53, p21 and CDK4 were also investigated and were inhibited by GS treatment. In conclusion, GS extract could be considered as an autophagy inducer in glioblastoma cells U87Mg. Full article
(This article belongs to the Special Issue The Role and Regulation of Autophagy in Cancer Cells)
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