Dear Colleagues,

The year 2023 marks the 10th anniversary of Biomedicines, a peer-reviewed open access journal in the biomedical field. So far, Biomedicines has published more than 2700 papers from more than 17,000 authors. We appreciate each author, reviewer, and academic editor whose support has brought us to where we are today.

To celebrate this significant milestone, we aim to publish a Special Issue titled “10th Anniversary of Biomedicines—Pathogenesis and Innovative Therapies in Ovarian Cancer (OC)”. OC is the most lethal gynecological disease and is characterized by heterogeneity, a high risk of relapse and the development of chemoresistance; thus, resulting in poor prognosis. Genetic and epigenetic factors and microenvironment characteristics influence the progression of the disease and its response to therapy.  To date, the cornerstone of treatment has been maximal-effort surgical cytoreduction combined with cytotoxic chemotherapy, mainly represented by combinations of carboplatin and paclitaxel, both in adjuvant and metastatic settings.  An estimated 80–85% of patients with OC who achieve full remission following first-line platinum-based therapy will develop disease recurrence, and the median survival for these patients ranges from 12 months to 24 months. Except for bevacizumab and poly ADP-ribose polymerase inhibitors, there are few other options for women with platinum-resistant OC. It is, therefore, particularly important to deepen the pathobiology of the tumor itself, and further understand how it is influenced by the microenvironment and by the genetic heterogeneity present not only in cancer from different patients, but also within a single cancer. A greater understanding of all these factors could be very useful in the development of more personalized therapies that maintain activity against resistant cells and take into account the specific characteristics of each individual tumor.

Dr. Francesca Magherini
Dr. Tania Gamberi
Guest Editors

Manuscript Submission Information

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