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Biomedicines
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10th Anniversary of Biomedicines—Advances in Cancer Invasion and Metastasis
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10th Anniversary of Biomedicines—Advances in Cancer Invasion and Metastasis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 6317

Special Issue Editor

Dr. Laura Rosano

E-Mail Website
Guest Editor
Institute of Molecular Biology and Pathology (IBPM) - National Research Council (CNR), Rome, Italy
Interests: cancer invasion and metastasis; invadopodia; cytoskeleton; 3D models; GPCR; Integrin; b-arrestin; endothelin; Rho GTPase

Special Issue Information

Dear Colleagues,

The year 2023 marks the 10th anniversary of Biomedicines, a peer-reviewed open access journal in the biomedical field. So far, Biomedicines has published more than 2700 papers from more than 17,000 authors. We appreciate each author, reviewer, and academic editor whose support has brought us to where we are today.

This Special Issue "10th Anniversary of Biomedicines—Advances in Cancer Invasion and Metastasis" aims to collect high-quality research articles and review articles covering recent advances in our understanding of the complicated regulatory network for the invasion, dissemination, and metastasis cascade and novel strategies to prevent the lethal spread of cancer. Topics relevant to this Special Issue include, but are not limited to, fundamental events underlying the dissemination of cancer cells from primary tumors, the establishment of a micro-metastases, metastatic outgrowth,  cancer cell metabolism, immune evasion, the crosstalk of cancer cells with the surrounding microenvironment and its modification, drug resistance, omics approaches, genetic and epigenetic regulation, diagnostic and prognostic biomarkers, new therapeutically exploitable mechanisms, and emerging strategies that are in the preclinical and clinical development to target pre-metastatic and metastatic disease.

Dr. Laura Rosano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • invasion
  • metastasis
  • tumor microevirnement
  • stromal cells
  • extracellular matrix
  • cell metabolism
  • epigenetic
  • preclinical models
  • immune evasion
  • drug resistance
  • biomarkers
  • omics
  • cancer
  • tumor stemness
  • drug screening
  • therapeutic target
  • cancer biology
  • immunotherapy
  • exosomes
  • precision medicine
  • mechanotransduction
  • cell plasticity
  • intratumoral heterogeneity
  • tumor evolution

Related Special Issue

Published Papers (3 papers)

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Research

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17 pages, 2726 KiB  
Article
Effects of the Exposure of Human Non-Tumour Cells to Sera of Pancreatic Cancer Patients
by Berina Sabanovic, Matteo Giulietti, Monia Cecati, Gaya Spolverato, Clara Benna, Salvatore Pucciarelli and Francesco Piva
Biomedicines 2022, 10(10), 2588; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10102588 - 15 Oct 2022
Cited by 1 | Viewed by 1452
Abstract
Pancreatic ductal adenocarcinoma (PDAC) has high metastatic potential. The “genometastasis” theory proposes that the blood of some cancer patients contains elements able to transform healthy cells by transferring oncogenes. Since findings on genometastasis in PDAC are still scarce, we sought supporting evidence by [...] Read more.
Pancreatic ductal adenocarcinoma (PDAC) has high metastatic potential. The “genometastasis” theory proposes that the blood of some cancer patients contains elements able to transform healthy cells by transferring oncogenes. Since findings on genometastasis in PDAC are still scarce, we sought supporting evidence by treating non-tumour HEK293T and hTERT-HPNE human cell lines with sera of PDAC patients. Here, we showed that HEK293T cells have undergone malignant transformation, increased the migration and invasion abilities, and acquired a partial chemoresistance, whereas hTERT-HPNE cells were almost refractory to transformation by patients’ sera. Next-generation sequencing showed that transformed HEK293T cells gained and lost several genomic regions, harbouring genes involved in many cancer-associated processes. Our results support the genometastasis theory, but further studies are needed for the identification of the circulating transforming elements. Such elements could also be useful biomarkers in liquid biopsy assays. Full article
(This article belongs to the Special Issue 10th Anniversary of Biomedicines—Advances in Cancer Invasion and Metastasis)
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Review

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20 pages, 1472 KiB  
Review
Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma
by Anastasios Goulioumis and Kostis Gyftopoulos
Biomedicines 2022, 10(9), 2148; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines10092148 - 01 Sep 2022
Cited by 3 | Viewed by 1943
Abstract
In epithelial neoplasms, such as laryngeal carcinoma, the survival indexes deteriorate abruptly when the tumor becomes metastatic. A molecular phenomenon that normally appears during embryogenesis, epithelial-to-mesenchymal transition (EMT), is reactivated at the initial stage of metastasis when tumor cells invade the adjacent stroma. [...] Read more.
In epithelial neoplasms, such as laryngeal carcinoma, the survival indexes deteriorate abruptly when the tumor becomes metastatic. A molecular phenomenon that normally appears during embryogenesis, epithelial-to-mesenchymal transition (EMT), is reactivated at the initial stage of metastasis when tumor cells invade the adjacent stroma. The hallmarks of this phenomenon are the abolishment of the epithelial and acquisition of mesenchymal traits by tumor cells which enhance their migratory capacity. EMT signaling is mediated by complex molecular pathways that regulate the expression of crucial molecules contributing to the tumor’s metastatic potential. Effectors of EMT include loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, neovascularization, acquisition of stem-cell properties, and the activation of tumor stroma. However, the current approach to EMT involves a holistic model that incorporates the acquisition of potentials beyond mesenchymal transition. As EMT is inevitably associated with a reverse mesenchymal-to-epithelial transition (MET), a model of partial EMT is currently accepted, signifying the cell plasticity associated with invasion and metastasis. In this review, we identify the cumulative evidence which suggests that various aspects of EMT theory apply to laryngeal carcinoma, a tumor of significant morbidity and mortality, introducing novel molecular targets with prognostic and therapeutic potential. Full article
(This article belongs to the Special Issue 10th Anniversary of Biomedicines—Advances in Cancer Invasion and Metastasis)
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Other

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9 pages, 3358 KiB  
Case Report
Extremely Rare Pulmonary Metastases of Skin Basal Cell Carcinoma: Report of Two Cases with Clinicopathological Features
by Małgorzata Edyta Wojtyś, Kajetan Kiełbowski, Michał Kunc, Seweryn Adam Skrzyniarz, Piotr Lisowski, Rafał Becht, Paulina Żukowska, Konrad Ptaszyński and Janusz Wójcik
Biomedicines 2023, 11(2), 283; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines11020283 - 19 Jan 2023
Viewed by 2369
Abstract
Basal cell carcinoma (BCC) is the most frequent human skin cancer, but metastasizing BCC (MBCC) is extremely rare, developing in approximately 0.0028% to 0.55% of BCC patients. Herein, we report two cases of pulmonary MBCC. The first one developed in a 72-year-old male [...] Read more.
Basal cell carcinoma (BCC) is the most frequent human skin cancer, but metastasizing BCC (MBCC) is extremely rare, developing in approximately 0.0028% to 0.55% of BCC patients. Herein, we report two cases of pulmonary MBCC. The first one developed in a 72-year-old male who underwent surgical resection due to multiple recurrences and adjuvant radiotherapy. Immunohistochemistry showed that neoplastic cells expressed Ber-EP4, CK5/6, p63, EMA (focally), BCL-2, and CD10, but were negative for CK7, CK20, S100, estrogen and progesterone receptors, and TTF-1. The second case is a 64-year-old female treated with vismodegib. Clinicopathological features and differential diagnoses are described. Full article
(This article belongs to the Special Issue 10th Anniversary of Biomedicines—Advances in Cancer Invasion and Metastasis)
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