Dear Colleagues,

G-protein-coupled receptors (GPCRs) are the cell surface protein that constitute the largest family in the human genome (>800gene), and are involved in a wide variety of function in the peripheral and central system. GPCRs, primarily confined within the plasma membrane, and their structural findings revealed that they consist of seven transmembrane-spanning α-helix domains linked by three altering intracellular and extracellular loops and N- and C-terminals. GPCRs have the ability to bind or are activated by multiple ligands, including hormones, photons, ions, neurotransmitters, odorants, peptides, and light, and are involved in the regulation of multiple signaling pathways. The majority of transduction events in cells are under the influence of GPCRs, which is a testament to their significance as a major target of therapeutic drug discovery; at present, >40% of therapeutic drugs represent GPCR, worth an estimated >$850 billion. In the last two decades, our understanding regarding GPCRs’ functionality and pharmacology has significantly changed. The concept that GPCRs exist and function in a monomeric entity has been rephrased, and growing pharmacological, biochemical, and biophysical evidence supports that GPCRs form functionally active homo- and hetero-dimers, even a higher order of oligomers, and modulate pharmacological properties and receptor mediated regulation of downstream signaling pathways that are different from the native receptor. Despite recent progress in the field of GPCRs, the structure biology of these surface proteins is poorly understood; however, functional interactions between different GPCRs, including adrenergic, cannabinoid, GABA, dopamine, opioid, and somatostatin receptor subtypes are now well established.

As Guest Editor, I invite submission of manuscripts dealing with different aspects of GPCRs for publication in this Special Issue of Biomedicine.

Prof. Ujendra Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• agonist
• dimerization
• G-proteins
• receptor coupling
• G-protein-coupled receptor kinases
• G-protein-coupled receptors
• internalization
• ligand binding
• monomers
• pharmacology phosphorylation
• signaling pathways