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Biomedicines
Special Issues
Disease-Focused Research Using Stem Cells 2.0
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Disease-Focused Research Using Stem Cells 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 8045

Special Issue Editor

Dr. Yohei Hayashi

E-Mail Website
Guest Editor
iPS Cell Advanced Characterization and Development Team BioResource Research Center, RIKEN, Tsukuba, JapanFaculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-0074, Japan
Interests: stem cell biology; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With advances in stem cell technologies, as well as with the recent availability of genome editing technologies, we can generate more complex and phenotypically accurate cellular models based on stem cells. Reprogramming technology, in particular, which can generate iPS (induced pluripotent stem) cells or directly transdifferentiated cells, enables us to recapitulate patients’ symptoms in vitro in cultured cells and/or in vivo in transplanted model animals. This opens new and exciting opportunities for stem cell utilization in early discovery, preclinical and translational research in drug development, and cell therapy.

This Special Issue of Biomedicines focuses on recent advances in disease modeling and regenerative medicine using stem cells. The goal is to demonstrate the conceptual and practical advances in order to expand the applications in this exciting field.

We encourage authors to submit original research and review articles where the focus is on various disease-focused studies using pluripotent stem cells and/or somatic stem cells. Potential topics include, but are not limited to:

  • Stem cell establishment and characterization
  • Development of genome-edited stem cells
  • Development of stem cell culture and handling (e.g., differentiation, sorting, preserving, or mass production) methods
  • Development of novel analysis methods using stem cells
  • Disease modeling using stem cells
  • Drug safety tests and screening using stem cells
  • Demonstration of stem cell transplantation for therapeutic purposes

Dr. Yohei Hayashi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • disease-specific iPS cells
  • disease modeling
  • phenotypic screening
  • safety test
  • mutations
  • genome editing
  • isogenic control cells
  • regenerative medicine
  • cell therapy
  • cell manufacturing

Related Special Issue

Published Papers (3 papers)

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Research

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13 pages, 1891 KiB  
Article
Generation of Functional Cardiomyocytes from Human Gastric Fibroblast-Derived Induced Pluripotent Stem Cells
by Chih-Hsien Wu, Hsuan-Hwai Lin, Yi-Ying Wu, Yi-Lin Chiu, Li-Yen Huang, Cheng-Chung Cheng, Chung-Chi Yang and Tsung-Neng Tsai
Biomedicines 2021, 9(11), 1565; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines9111565 - 29 Oct 2021
Viewed by 1787
Abstract
Coronary artery diseases are major problems of the world. Coronary artery disease patients frequently suffer from peptic ulcers when they receive aspirin treatment. For diagnostic and therapeutic purposes, the implementation of panendoscopy (PES) with biopsy is necessary. Some biopsy samples are wasted after [...] Read more.
Coronary artery diseases are major problems of the world. Coronary artery disease patients frequently suffer from peptic ulcers when they receive aspirin treatment. For diagnostic and therapeutic purposes, the implementation of panendoscopy (PES) with biopsy is necessary. Some biopsy samples are wasted after the assay is completed. In the present study, we established a protocol for human gastric fibroblast isolation and induced pluripotent stem cell (iPSC) generation from gastric fibroblasts via PES with biopsy. We showed that these iPSCs can be differentiated into functional cardiomyocytes in vitro. To our knowledge, this is the first study to generate iPSCs from gastric fibroblasts in vitro. Full article
(This article belongs to the Special Issue Disease-Focused Research Using Stem Cells 2.0)
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24 pages, 327 KiB  
Review
Stem Cells in the Path of Light, from Corneal to Retinal Reconstruction
by Ovidiu Samoila and Lacramioara Samoila
Biomedicines 2021, 9(8), 873; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines9080873 - 23 Jul 2021
Cited by 3 | Viewed by 1967
Abstract
The future of eye reconstruction invariably includes stem cells transplantation. Corneal limbus, corneal stroma, trabeculum, retinal cells, optic nerve, and all structures that are irreversibly damaged and have no means to be repaired or replaced, through conventional treatment or surgery, represent targets for [...] Read more.
The future of eye reconstruction invariably includes stem cells transplantation. Corneal limbus, corneal stroma, trabeculum, retinal cells, optic nerve, and all structures that are irreversibly damaged and have no means to be repaired or replaced, through conventional treatment or surgery, represent targets for stem cell reconstruction. This review tries to answer the question if there is any clinical validation for stem therapies, so far, starting from the cornea and, on the path of light, arriving to the retina. The investigation covers the last 10 years of publications. From 2385 published sources, we found 56 clinical studies matching inclusion criteria, 39 involving cornea, and 17 involving retina. So far, corneal epithelial reconstruction seems well validated clinically. Enough clinical data are collected to allow some form of standardization for the stem cell transplant procedures. Cultivated limbal epithelial stem cells (CLET), simple limbal epithelial transplant (SLET), and oral mucosa transplantation are implemented worldwide. In comparison, far less patients are investigated in retinal stem reconstructions, with lower anatomical and clinical success, so far. Intravitreal, subretinal, and suprachoroidal approach for retinal stem therapies face specific challenges. Full article
(This article belongs to the Special Issue Disease-Focused Research Using Stem Cells 2.0)
34 pages, 433 KiB  
Review
Cell-Based Therapies for Traumatic Brain Injury: Therapeutic Treatments and Clinical Trials
by Celia Bonilla and Mercedes Zurita
Biomedicines 2021, 9(6), 669; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines9060669 - 10 Jun 2021
Cited by 27 | Viewed by 3652
Abstract
Traumatic brain injury (TBI) represents physical damage to the brain tissue that induces transitory or permanent neurological disabilities. TBI contributes to 50% of all trauma deaths, with many enduring long-term consequences and significant medical and rehabilitation costs. There is currently no therapy to [...] Read more.
Traumatic brain injury (TBI) represents physical damage to the brain tissue that induces transitory or permanent neurological disabilities. TBI contributes to 50% of all trauma deaths, with many enduring long-term consequences and significant medical and rehabilitation costs. There is currently no therapy to reverse the effects associated with TBI. An increasing amount of research has been undertaken regarding the use of different stem cells (SCs) to treat the consequences of brain damage. Neural stem cells (NSCs) (adult and embryonic) and mesenchymal stromal cells (MSCs) have shown efficacy in pre-clinical models of TBI and in their introduction to clinical research. The purpose of this review is to provide an overview of TBI and the state of clinical trials aimed at evaluating the use of stem cell-based therapies in TBI. The primary aim of these studies is to investigate the safety and efficacy of the use of SCs to treat this disease. Although an increasing number of studies are being carried out, few results are currently available. In addition, we present our research regarding the use of cell therapy in TBI. There is still a significant lack of understanding regarding the cell therapy mechanisms for the treatment of TBI. Thus, future studies are needed to evaluate the feasibility of the transplantation of SCs in TBI. Full article
(This article belongs to the Special Issue Disease-Focused Research Using Stem Cells 2.0)
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