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Biomedicines
Special Issues
10th Anniversary of Biomedicines—Mechanisms of Inflammation
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10th Anniversary of Biomedicines—Mechanisms of Inflammation

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 2163

Special Issue Editor

Prof. Dr. Bernhard Ryffel

E-Mail Website
Guest Editor
CNRS, INEM, UMR7355, University of Orleans, 45071 Orleans, France
Interests: injury-induced inflammation; chronic progressive respiratory diseases; viral superinfection; innate immune danger sensing; cGAS/STING; inflammasome activation; IL-1 family; Th2; Th17; altered microbiota; metabolites; tissue homeostasis; inflammatory responses; translational research in mouse models of human disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The year 2023 marks the 10th anniversary of Biomedicines, a peer-reviewed open access journal in the biomedical field. So far, Biomedicines has published more than 2700 papers from more than 17,000 authors. We appreciate each author, reviewer, and academic editor whose support has brought us to where we are today.

To celebrate this significant milestone, we aim to publish a Special Issue entitled 10th Anniversary of Biomedicines—Advances in Mechanisms of Inflammation. Inflammation is a critical innate immune response of the host to tissue injury, infection and environmental pollution. Recent research identified endogenous danger signals with activate different pathways such as TLR, inflammasome and cGAS/STING resulting in myeloid cell recruitment and activation This process is associated with the release of mediators such IL-1b TNFa, Interferons, which enhance tissue damage and cell death, leading progressive disease, tissue fibrosis or repair. The factors controlling inflammation are an area of intense research and include innate lymphoid cells, metabolites, microbiota, neuroendocrine mediators, which are emerging and may identify novel drug targets. This Special Issue of Biomedicines attempts to investigate mechanisms of Inflammation. Original articles and reviews are welcome for the topic.

Prof. Dr. Bernhard Ryffel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • TLR
  • NLR
  • cGAS/STING
  • IL-1b
  • IL-18
  • TNFa
  • Interferons
  • prostaglandins
  • TGFb
  • IL-10
  • resolvins
  • neutrophils
  • monocytes
  • eosinophils
  • platelets, lymphocytes
  • innate lymphoid cells
  • NK cells
  • metabolites
  • microbiota
  • neuroendocrine mediators
  • acetyl choline
  • adrenaline
  • neuropeptide

Published Papers (1 paper)

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Research

9 pages, 689 KiB  
Article
Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients
by Michela D’Ascanio, Fausta Viccaro, Dario Pizzirusso, Giulio Guerrieri, Alessandra Pagliuca, Simone Guerrini, Marta Innammorato, Claudia De Vitis, Salvatore Raffa, Aldo Pezzuto and Alberto Ricci
Biomedicines 2023, 11(1), 124; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines11010124 - 04 Jan 2023
Cited by 3 | Viewed by 1666
Abstract
Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study [...] Read more.
Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study is to explore the relationship between surfactant protein B (Sp-B) serum levels and clinical, radiological, and functional pulmonary parameters in COPD patients. Methods: Forty COPD patients and twenty smokers without airflow limitations or respiratory symptoms were enrolled. Each patient was given questionnaires (CAT and mMRC) and 6MWT, spirometry, DLCO, and computer tomography (CT) were performed. All participants underwent a venous blood sample drawing, and quantitative detection of their Sp-B plasma levels was performed by an enzyme-linked immunosorbent assay. The spirometry and Sp-B plasma levels were assessed after 12 months. Results: A statistically significant difference was found in the plasma Sp-B levels between COPD patients compared to the other group (4.72 + 3.2 ng/mL vs. 1.78 + 1.5 ng/mL; p < 0.001). The change in FEV1 after 12 months (Delta FEV1) showed a significantly negative correlation with respect to the change in Sp-B levels (Delta SpB) (r = −0.4; p < 0.05). This correlation indicates that increasing the plasma dosage of SpB is a foretoken of functional decline. Conclusions: SpB may be considered as a useful marker in COPD assessment and provides prognostic information on lung functional decline. Despite its usefulness, further studies are needed to define its reliability as a biomarker. Full article
(This article belongs to the Special Issue 10th Anniversary of Biomedicines—Mechanisms of Inflammation)
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