Special Issue "Novel Evidence about Hydrogen Sulfide (H2S)-Donor Molecules as Innovative Therapeutical Tools"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 17 December 2021.

Special Issue Editors

Prof. Dr. Alma Martelli
E-Mail Website
Guest Editor
Department of Pharmacy, Università di Pisa, Pisa, Italy
Interests: cardiovascular pharmacology; gasotransmitters; nutraceuticals; hydrogen sulfide; Brassicaceae; isothiocyanates; vascular inflammation; aging; endothelial dysfunction; hypertension; H2S-donors; polyphenols; nitric oxide; vascular inflammation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Vincenzo Calderone
E-Mail Website
Guest Editor
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
Interests: preclinical pharmacology; cardiovascular pharmacology; drug discovery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years the role of hydrogen sulfide (H2S) as endogenous pleiotropic gasotransmitter involved in the maintenance of homeostasis has been demonstrated and as a further confirmation, a decrease of H2S endogenous levels has been recorded in many pathological conditions. On these bases, the research and characterization of H2S-donor molecules, able to release H2S in a slow and gradual way, similar to the physiological production, represents the goal of many excellent research groups around the world. The aim of this special issue is to collect novel evidence about these H2S-releasing drugs in order to consider them as innovative therapeutical tools for unmet medical needs.

Prof. Alma Martelli
Prof. Vincenzo Calderone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hydrogen sulfide(H2S)-donor
  • H2S-releasing molecule
  • H2S-hybrid drug
  • Hydrogen sulfide
  • Therapeutical tool

Published Papers (1 paper)

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Review

Review
The Role of Hydrogen Sulfide in Respiratory Diseases
Biomolecules 2021, 11(5), 682; https://0-doi-org.brum.beds.ac.uk/10.3390/biom11050682 - 01 May 2021
Cited by 4 | Viewed by 918
Abstract
Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H2 [...] Read more.
Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H2S) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Recently, the therapeutic potential of H2S for respiratory diseases has been widely investigated. H2S plays a vital therapeutic role in obstructive respiratory disease, pulmonary fibrosis, emphysema, pancreatic inflammatory/respiratory lung injury, pulmonary inflammation, bronchial asthma and bronchiectasis. Although the therapeutic role of H2S has been extensively studied in various respiratory diseases, a concrete literature review will have an extraordinary impact on future therapeutics. This review provides a comprehensive overview of the effective role of H2S in respiratory diseases. Besides, we also summarized H2S production in the lung and its metabolism processes in respiratory diseases. Full article
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