Novel Evidence about Hydrogen Sulfide (H2S)-Donor Molecules as Innovative Therapeutical Tools

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (17 December 2021) | Viewed by 10566

Special Issue Editors

1. Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
2. Interdepartmental Research Centre "Nutraceuticals and Food for Health (NUTRAFOOD)", University of Pisa, 56126 Pisa, Italy
3. Interdepartmental Research Centre of "Ageing Biology and Pathology", University of Pisa, 56126 Pisa, Italy
Interests: cardiovascular pharmacology; gasotransmitters; nutraceuticals; hydrogen sulfide; brassicaceae; isothiocyanates; vascular inflammation; aging; endothelial dysfunction; hypertension; H2S-donors
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Special Issue Information

Dear Colleagues,

In recent years the role of hydrogen sulfide (H2S) as endogenous pleiotropic gasotransmitter involved in the maintenance of homeostasis has been demonstrated and as a further confirmation, a decrease of H2S endogenous levels has been recorded in many pathological conditions. On these bases, the research and characterization of H2S-donor molecules, able to release H2S in a slow and gradual way, similar to the physiological production, represents the goal of many excellent research groups around the world. The aim of this special issue is to collect novel evidence about these H2S-releasing drugs in order to consider them as innovative therapeutical tools for unmet medical needs.

Dr. Alma Martelli
Prof. Dr. Vincenzo Calderone
Guest Editors

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Keywords

  • hydrogen sulfide (H2S)-donor
  • H2S-releasing molecule
  • H2S-hybrid drug
  • hydrogen sulfide
  • therapeutical tool

Published Papers (2 papers)

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Review

51 pages, 16115 KiB  
Review
H2S Donors and Their Use in Medicinal Chemistry
by Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Giuseppe Caliendo, Angela Corvino, Gianluca Esposito, Giovanna Esposito, Ferdinando Fiorino, Marco Migliaccio, Antonia Scognamiglio, Beatrice Severino, Rosa Sparaco and Francesco Frecentese
Biomolecules 2021, 11(12), 1899; https://0-doi-org.brum.beds.ac.uk/10.3390/biom11121899 - 18 Dec 2021
Cited by 36 | Viewed by 4163
Abstract
Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). [...] Read more.
Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H2S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H2S levels has a potential therapeutic value. Consequently, synthetic H2S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H2S donors; furthermore, herein we discuss their preparation, the H2S-releasing mechanisms, and their -biological applications. Full article
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25 pages, 2457 KiB  
Review
The Role of Hydrogen Sulfide in Respiratory Diseases
by Saadullah Khattak, Qian-Qian Zhang, Muhammad Sarfraz, Pir Muhammad, Ebenezeri Erasto Ngowi, Nazeer Hussain Khan, Saqib Rauf, Yi-Zhen Wang, Hui-Wen Qi, Di Wang, Attia Afzal, Xin-Ying Ji and Dong-Dong Wu
Biomolecules 2021, 11(5), 682; https://0-doi-org.brum.beds.ac.uk/10.3390/biom11050682 - 01 May 2021
Cited by 27 | Viewed by 4943
Abstract
Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H2 [...] Read more.
Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H2S) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Recently, the therapeutic potential of H2S for respiratory diseases has been widely investigated. H2S plays a vital therapeutic role in obstructive respiratory disease, pulmonary fibrosis, emphysema, pancreatic inflammatory/respiratory lung injury, pulmonary inflammation, bronchial asthma and bronchiectasis. Although the therapeutic role of H2S has been extensively studied in various respiratory diseases, a concrete literature review will have an extraordinary impact on future therapeutics. This review provides a comprehensive overview of the effective role of H2S in respiratory diseases. Besides, we also summarized H2S production in the lung and its metabolism processes in respiratory diseases. Full article
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