Special Issue "TGF-Beta Signaling in Physiology and Pathology"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (15 February 2020).
Special Issues and Collections in MDPI journals
The transforming growth factor b (TGF-β) family of cytokines comprises the TGF-β ligands (TGF-β1, TGF-β2, and TGF-β3) and the closely related bone morphogenetic proteins (BMPs), activins, and growth and differentiation factors (GDFs). These soluble factors exhibit tissue-specific effects through their interaction with cell membrane receptor complexes, which upon activation, activate cellular responses such as proliferation, differentiation, apoptosis, migration, adhesion, cytoskeletal organization, and extracellular matrix (ECM) production. Due to its key role in cell homeostasis, the signal transduction initiated by members of the TGF-β family is tightly controlled at multiple levels, for example, by means of extracellular antagonists, co-receptor molecules, and intracellular regulators.
TGF-β signaling plays multiple functions in development and adulthood, and genetic or environmental factors disturbing TGF-β signaling often result in a variety of pathologies, including cancer, cardiovascular disease, fibrosis, and skeletal disorders. Therefore, the elucidation of the mechanisms responsible for aberrant TGF-β signaling will contribute to the development of novel therapeutic approaches for multiple human diseases. This Special Issue aims to collect and summarize recent findings and developments in different areas of the field of TGF-β-driven (patho)physiology.
Prof. Marie-José Goumans
Dr. Gonzalo Sánchez-Duffhues
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Signal transduction