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Journals
Biomolecules
Special Issues
Biomarkers in Urologic Oncology
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Biomarkers in Urologic Oncology

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 1949

Special Issue Editor

Dr. Tvrtko Hudolin

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Guest Editor
Department of Urology, Zagreb University Hospital Center, Zagreb, Croatia
Interests: urologic oncology; kidney; cancer; prostate cancer; bladder cancer; testis cancer; tumor antigens; MAGE; NY-ESO-1; IDO; p53; BMP; aminoacyl-tRNA synthetases; kidney transplantation

Special Issue Information

Dear Colleagues,

The number of new biomarkers in medicine is significantly increasing. Some have just been discovered and have a long way to go from validation to clinical practice, while others are well established and have been used for decades in many ways, from diagnosis to selecting the best treatment options, and predicting disease recurrence and disease-free survival to follow-up.

Biomarkers such as prostate specific antigen (PSA) or prostate specific membrane antigen (PSMA) for prostate cancer or alpha fetoprotein (AFP) and beta human chorionic gonadotropin (beta-hCG) for testicular cancer are well known in urology. However, there are also new biomarkers for prostate, testicular, bladder, and kidney cancers based on DNA, RNA, proteins, peptides, or other biomolecules. The topic of biomarkers in urologic oncology is very exciting and can change the way in which we approach and treat our patients. In this issue, original manuscripts and reviews dealing with any aspect of various biomarkers in kidney, bladder, prostate, and testicular cancer are very welcome.


Dr. Tvrtko Hudolin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • kidney cancer
  • bladder cancer
  • testis cancer

Published Papers (1 paper)

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Research

16 pages, 2065 KiB  
Article
Prostate Cancer-Associated miRNAs in Saliva: First Steps to an Easily Accessible and Reliable Screening Tool
by Christoph Luedemann, Jan-Ludwig Reinersmann, Claudia Klinger, Stephan Degener, Nici Markus Dreger, Stephan Roth, Michael Kaufmann and Andreas Savelsbergh
Biomolecules 2022, 12(10), 1366; https://0-doi-org.brum.beds.ac.uk/10.3390/biom12101366 - 24 Sep 2022
Cited by 6 | Viewed by 1592 | Correction
Abstract
Background: Common diagnostic tools for prostate cancer—prostate-specific antigen and transrectal biopsy—show only low predictive value and poor sensitivity. This study examines circulating miRNA in saliva to explore the possibility of a non-invasive and easy-to-execute diagnostic tool for prostate cancer screenings. Methods: 16 miRNAs [...] Read more.
Background: Common diagnostic tools for prostate cancer—prostate-specific antigen and transrectal biopsy—show only low predictive value and poor sensitivity. This study examines circulating miRNA in saliva to explore the possibility of a non-invasive and easy-to-execute diagnostic tool for prostate cancer screenings. Methods: 16 miRNAs were extracted from salivary exosomes and analyzed via the delta-CT method. The presented method enables an application of the test in any health institution and even outpatient sector. Recruited participants were suspected to suffer from prostate cancer due to elevated PSA serum levels. Of these participants, 43 were diagnosed with prostate cancer, while 31 suffered from benign diseases and served as control group. Results: hsa-mir-331-3p and hsa-mir-200b were significantly reduced in prostate cancer patients compared to the control group. ROC curve analysis revealed a reliable differentiation strength (AUC > 0.6) for both miRNAs with positive predictive values of 71% indicating prostate cancer. Differentiation of both groups based on PSA serum measurements was insufficient. The other 14 examined miRNAs showed no significant group differences. Conclusions: The presented method and miRNA are promising non-invasive tools to augment the current prostate cancer screening, thereby improving screening sensitivity and reducing numbers of false positive cancer suspects admitted to further invasive diagnostic and therapeutic steps. Full article
(This article belongs to the Special Issue Biomarkers in Urologic Oncology)
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