Special Issue "Feature Issue of Biosensors and Bioelectronic Devices Section"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Cecilia Cristea
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Guest Editor
Analytical Chemistry Department, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy 4, Louis Pasteur St., Cluj-Napoca, 400349 Cluj, Romania
Interests: electrochemical and optical sensors; graphene; nanomaterials based electrodes; bioanalysis
Special Issues and Collections in MDPI journals
Dr. Mihaela Tertis
E-Mail Website
Guest Editor
Analytical Chemistry Department, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy 4, Louis Pasteur St., Cluj-Napoca, 400349 Cluj, Romania
Interests: analytical chemistry; electrochemistry, electrochemical (bio)sensors; graphene; composite materials for electrode functionalization; biomedical and environmental applications
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The field of biosensors and bioelectronic devices has great potential for miniaturization, low-cost, fast and sensitive analytical detection strategies and devices. In recent decades, tremendous progress in the translation of electrochemical and optical biosensors from theory and fundamental research to practical implementation in bioanalysis and sensing technology has been achieved. Furthermore, technological development has materialized recently through the incorporation of microfluidic, screen-printed and multiplex analytical devices for qualitative and quantitative analysis of a whole spectrum of individual ions, small molecules, peptides, proteins, nucleic oligoes, cells, and much more. This progress makes biosensors highly important tools in different fields, such as biomedicine, environment, food and agriculture. Many of the applications developed so far, with the help of biosensors and bioelectronic devices, are characterized by high sensitivity, high performance in real-time monitoring of processes, and multiplex capability in diagnostic practice.

This Special Issue will be composed of original research articles, short communications, as well as review-type articles (e.g., comprehensive and critical literature reviews or review studies based on the author’s recent research experience).

In this regard, it is our pleasure to invite you to contribute to this Special Issue focusing on the most recent developments and future perspectives for biosensors, biosensing strategies and bioelectronic devices applied in vital fields such as biomedicine and the environment.

You may also consider that we plan to convert all the published submissions into a book on the same topic.

Prof. Dr. Cecilia Cristea
Dr. Mihaela Tertis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sensors
  • biosensors
  • bioelectronic devices
  • printed sensors
  • environmental monitoring
  • healthcare applications
  • miniaturization
  • portability
  • disposable (bio)sensors

Published Papers (5 papers)

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Research

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Article
An FPGA-Based Machine Learning Tool for In-Situ Food Quality Tracking Using Sensor Fusion
Biosensors 2021, 11(10), 366; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11100366 - 30 Sep 2021
Viewed by 358
Abstract
The continuous development of more accurate and selective bio- and chemo-sensors has led to a growing use of sensor arrays in different fields, such as health monitoring, cell culture analysis, bio-signals processing, or food quality tracking. The analysis and information extraction from the [...] Read more.
The continuous development of more accurate and selective bio- and chemo-sensors has led to a growing use of sensor arrays in different fields, such as health monitoring, cell culture analysis, bio-signals processing, or food quality tracking. The analysis and information extraction from the amount of data provided by these sensor arrays is possible based on Machine Learning techniques applied to sensor fusion. However, most of these computing solutions are implemented on costly and bulky computers, limiting its use in in-situ scenarios outside complex laboratory facilities. This work presents the application of machine learning techniques in food quality assessment using a single Field Programmable Gate Array (FPGA) chip. The characteristics of low-cost, low power consumption as well as low-size allow the application of the proposed solution even in space constrained places, as in food manufacturing chains. As an example, the proposed system is tested on an e-nose developed for beef classification and microbial population prediction. Full article
(This article belongs to the Special Issue Feature Issue of Biosensors and Bioelectronic Devices Section)
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Article
In-Situ Monitoring of Real-Time Loop-Mediated Isothermal Amplification with QCM: Detecting Listeria monocytogenes
Biosensors 2021, 11(9), 308; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11090308 - 31 Aug 2021
Viewed by 925
Abstract
Functionalized DNA sequences are promising sensing elements to combine with transducers for bio-sensing specific target microbes. As an application example, this paper demonstrates in situ detection of loop-mediated isothermal amplification products by hybridizing them with thiolated-ssDNA covalently anchored on the electrodes of a [...] Read more.
Functionalized DNA sequences are promising sensing elements to combine with transducers for bio-sensing specific target microbes. As an application example, this paper demonstrates in situ detection of loop-mediated isothermal amplification products by hybridizing them with thiolated-ssDNA covalently anchored on the electrodes of a quartz crystal microbalance (QCM). Such hybridization leads to a frequency signal, which is suitable for monitoring real-time LAMP amplification based on mass-sensing: it detects interactions between the complementary nucleobases of LAMP products in solution and the thiolated-ssDNA probe sequence on the gold surface. Target DNA LAMP products cause irreversible frequency shifts on the QCM surfaces during hybridization in the kHz range, which result from both changes in mass and charge on the electrode surface. In order to confirm the LAMP assay working in the QCM sensing system at elevated temperature, the sky blue of positive LAMP products solution was achieved by using the Hydroxy Naphthol Blue (HNB) and agarose gel electrophoresis. Since on-QCM sensing of DNA hybridization leads to irreversible sensor responses, this work shows characterization by X-ray photoelectron spectroscopy (XPS) core spectra of S2p, N1s, Mg1s, P2p and C1s. XPS results confirmed that indeed both DNA and by-products of LAMP attached to the surface. Listeria monocytogenes DNA served to study in-situ detection of amplified LAMP products on DNA-functionalized surfaces. Full article
(This article belongs to the Special Issue Feature Issue of Biosensors and Bioelectronic Devices Section)
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Article
DNA Aptamer Functionalized Hydrogels for Interferometric Fiber-Optic Based Continuous Monitoring of Potassium Ions
Biosensors 2021, 11(8), 266; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11080266 - 06 Aug 2021
Viewed by 769
Abstract
In the present paper, we describe a potassium sensor based on DNA-aptamer functionalized hydrogel, that is capable of continuous label-free potassium ion (K+) monitoring with potential for in situ application. A hydrogel attached to the end of an optical fiber is [...] Read more.
In the present paper, we describe a potassium sensor based on DNA-aptamer functionalized hydrogel, that is capable of continuous label-free potassium ion (K+) monitoring with potential for in situ application. A hydrogel attached to the end of an optical fiber is designed with di-oligonucleotides grafted to the polymer network that may serve as network junctions in addition to the covalent crosslinks. Specific affinity toward K+ is based on exploiting a particular aptamer that exhibits conformational transition from single-stranded DNA to G-quadruplex formed by the di-oligonucleotide in the presence of K+. Integration of this aptamer into the hydrogel transforms the K+ specific conformational transition to a K+ concentration dependent deswelling of the hydrogel. High-resolution interferometry monitors changes in extent of swelling at 1 Hz and 2 nm resolution for the hydrogel matrix of 50 µm. The developed hydrogel-based biosensor displayed high selectivity for K+ ions in the concentration range up to 10 mM, in the presence of physiological concentrations of Na+. Additionally, the concentration dependent and selective K+ detection demonstrated in the artificial blood buffer environment, both at room and physiological temperatures, suggests substantial potential for practical applications such as monitoring of potassium ion concentration in blood levels in intensive care medicine. Full article
(This article belongs to the Special Issue Feature Issue of Biosensors and Bioelectronic Devices Section)
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Article
Clinical Application of the Novel Cell-Based Biosensor for the Ultra-Rapid Detection of the SARS-CoV-2 S1 Spike Protein Antigen: A Practical Approach
Biosensors 2021, 11(7), 224; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11070224 - 06 Jul 2021
Cited by 3 | Viewed by 1126
Abstract
The availability of antigen tests for SARS-CoV-2 represents a major step for the mass surveillance of the incidence of infection, especially regarding COVID-19 asymptomatic and/or early-stage patients. Recently, we reported the development of a Bioelectric Recognition Assay-based biosensor able to detect the SARS-CoV-2 [...] Read more.
The availability of antigen tests for SARS-CoV-2 represents a major step for the mass surveillance of the incidence of infection, especially regarding COVID-19 asymptomatic and/or early-stage patients. Recently, we reported the development of a Bioelectric Recognition Assay-based biosensor able to detect the SARS-CoV-2 S1 spike protein expressed on the surface of the virus in just three minutes, with high sensitivity and selectivity. The working principle was established by measuring the change of the electric potential of membrane-engineered mammalian cells bearing the human chimeric spike S1 antibody after attachment of the respective viral protein. In the present study, we applied the novel biosensor to patient-derived nasopharyngeal samples in a clinical set-up, with absolutely no sample pretreatment. More importantly, membrane-engineered cells were pre-immobilized in a proprietary biomatrix, thus enabling their long-term preservation prior to use as well as significantly increasing their ease-of-handle as test consumables. The plug-and-apply novel biosensor was able to detect the virus in positive samples with a 92.8% success rate compared to RT-PCR. No false negative results were recorded. These findings demonstrate the potential applicability of the biosensor for the early, routine mass screening of SARS-CoV-2 on a scale not yet realized. Full article
(This article belongs to the Special Issue Feature Issue of Biosensors and Bioelectronic Devices Section)
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Review

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Review
Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications
Biosensors 2021, 11(4), 107; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11040107 - 04 Apr 2021
Cited by 1 | Viewed by 1415
Abstract
Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Among them, flexible optical platforms have the [...] Read more.
Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Among them, flexible optical platforms have the advantage of adapting to non-planar surfaces, suitable for in vivo and real-time monitoring of diseases and assessment of food safety. In this review, we summarize the newest and most advanced platforms coupling optically active materials (noble metal nanoparticles) and flexible substrates giving rise to hybrid nanomaterials and/or nanocomposites, whose performances are comparable to the ones obtained with hard substrates (e.g., glass and semiconductors). We focus on localized surface plasmon resonance (LSPR)-based and surface-enhanced Raman spectroscopy (SERS)-based biosensors. We show that large-scale, cost-effective plasmonic platforms can be realized with the currently available techniques and we emphasize the open issues associated with this topic. Full article
(This article belongs to the Special Issue Feature Issue of Biosensors and Bioelectronic Devices Section)
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