Electrochemical Bioassays for Cancer Diagnosis and Management

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 2886

Special Issue Editor


E-Mail Website
Guest Editor
Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain
Interests: aptamers; electrochemistry; nucleic acid-based biosensors; DNA isothermal amplification; clinical diagnosis; food safety control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increase in life expectancy along with poor habits have made cancer a highly prevalent disease worldwide, constituting a major challenge of modern medicine. Early cancer diagnosis, even before clinical symptoms, is the key to minimize cancer-related deaths and reduce the healthcare expenditure of cancer care. Likewise, prognosis, surveillance, and treatment response evaluation are of great importance. Liquid biopsy is a promising strategy to tackle these important challenges, but it is conditioned by the availability of biomarkers with the required sensitivity and clinical specificity, present in accessible biological fluids, whose search is a continually evolving and developing area. Electrochemical platforms/approaches in combination with traditional (antibodies and hybridization nucleic acid probes) or novel synthetic bioreceptors (PNAs, LNAs, aptamers, and affibodies, among others) are turning out to be well-suited in this emerging field.

The aim of this Special Issue is to highlight the latest advances in electrochemical sensing technologies with application in cancer diagnosis and management. Thus, approaches leading to boost both analytical sensitivity and selectivity (such as the employment of nanomaterials and nucleic acids modifying enzymes) are welcome. Authors are kindly invited to share their research innovations as well as reviews of the state of the art in this field.

Dr. Rebeca Miranda-Castro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cancer diagnosis
  • Cancer management
  • Cancer non-invasive biomarkers
  • Electrochemical detection platforms
  • Natural and synthetic bioreceptors
  • Nucleic acid-based assays
  • Aptamer-based assays
  • Immunoassays
  • Signal amplification strategies
  • Nanomaterials

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 2647 KiB  
Article
A Multianalyte Electrochemical Genosensor for the Detection of High-Risk HPV Genotypes in Oral and Cervical Cancers
by Thanyarat Chaibun, Patcharanin Thanasapburachot, Patutong Chatchawal, Lee Su Yin, Sirimanas Jiaranuchart, Patcharee Jearanaikoon, Chamras Promptmas, Waranun Buajeeb and Benchaporn Lertanantawong
Biosensors 2022, 12(5), 290; https://0-doi-org.brum.beds.ac.uk/10.3390/bios12050290 - 02 May 2022
Cited by 7 | Viewed by 2438
Abstract
Infection with high-risk human papillomavirus (HPV) is a major risk factor for oral and cervical cancers. Hence, we developed a multianalyte electrochemical DNA biosensor that could be used for both oral and cervical samples to detect the high-risk HPV genotypes 16 and 18. [...] Read more.
Infection with high-risk human papillomavirus (HPV) is a major risk factor for oral and cervical cancers. Hence, we developed a multianalyte electrochemical DNA biosensor that could be used for both oral and cervical samples to detect the high-risk HPV genotypes 16 and 18. The assay involves the sandwich hybridization of the HPV target to the silica-redox dye reporter probe and capture probe, followed by electrochemical detection. The sensor was found to be highly specific and sensitive, with a detection limit of 22 fM for HPV-16 and 20 fM for HPV-18, between the range of 1 fM and 1 µM. Evaluation with oral and cervical samples showed that the biosensor result was consistent with the nested PCR/gel electrophoresis detection. The biosensor assay could be completed within 90 min. Due to its simplicity, rapidity, and high sensitivity, this biosensor could be used as an alternative method for HPV detection in clinical laboratories as well as for epidemiological studies. Full article
(This article belongs to the Special Issue Electrochemical Bioassays for Cancer Diagnosis and Management)
Show Figures

Figure 1

Back to TopTop