Advances in Microfluidic Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 6683

Special Issue Editor

Institute of Physics, Czech Academy of Sciences, 182 51 Prague, Czech Republic
Interests: microfluidics; transport phenomena; biosensors; catalysis; polymer brushes; additive manufacturing

Special Issue Information

Dear Colleagues,

Since their widespread adoption in the mid-1990s, microfluidic technologies have progressed from a specialty topic to one that is nearly ubiquitous within the physical and biological sciences—an increase in usage that has also been witnessed within the biosensing world. The small dimensions of a microchannel provide a number of benefits to a biosensor, including increases in sensitivity, reductions in the sample volume required for analysis, and decreases in the size of the overall biosensor.

The initial combinations of microfluidics with biosensors were relatively simple, for example, a planar microchannel used to deliver a sample to the surface of a biosensor. Later, more advanced systems emerged, which have further pushed the boundaries of optimal biosensing operation: microfluidic mixers have been used to increase mass transport of analyte (and further increase the biosensor’s sensitivity); internal microfluidic valving allows a user to rapidly switch between fluidic samples for analysis; and passive pumping methods (or embedded active pumps) allow for further device miniaturization. Because of the colossal variety in biosensor types or, rather, the large range of transduction methods, biocomponents, and electronic packages that constitute a biosensor, the range and style of these associated microfluidic systems is also very large. Modern microfluidic biosensors now range from those based on the ever-popular PDMS, to paper-based flow devices, and to more exotic materials having more robust (and modifiable) characteristics. There has also been a rapid rise in the use of 3D printing to fabricate microfluidics for biosensing systems, which has tremendous potential for the incorporation of more complex fluidic functionalities. The future of this partnership between microfluidics and biosensors continues to lay the foundation for the next generation of biosensors. 

Dr. Nicholas Scott Lynn Jr.
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

29 pages, 5304 KiB  
Review
Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles
by Se-woon Choe, Bumjoo Kim and Minseok Kim
Biosensors 2021, 11(11), 464; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11110464 - 18 Nov 2021
Cited by 13 | Viewed by 6273
Abstract
Separation of micro- and nano-sized biological particles, such as cells, proteins, and nucleotides, is at the heart of most biochemical sensing/analysis, including in vitro biosensing, diagnostics, drug development, proteomics, and genomics. However, most of the conventional particle separation techniques are based on membrane [...] Read more.
Separation of micro- and nano-sized biological particles, such as cells, proteins, and nucleotides, is at the heart of most biochemical sensing/analysis, including in vitro biosensing, diagnostics, drug development, proteomics, and genomics. However, most of the conventional particle separation techniques are based on membrane filtration techniques, whose efficiency is limited by membrane characteristics, such as pore size, porosity, surface charge density, or biocompatibility, which results in a reduction in the separation efficiency of bioparticles of various sizes and types. In addition, since other conventional separation methods, such as centrifugation, chromatography, and precipitation, are difficult to perform in a continuous manner, requiring multiple preparation steps with a relatively large minimum sample volume is necessary for stable bioprocessing. Recently, microfluidic engineering enables more efficient separation in a continuous flow with rapid processing of small volumes of rare biological samples, such as DNA, proteins, viruses, exosomes, and even cells. In this paper, we present a comprehensive review of the recent advances in microfluidic separation of micro-/nano-sized bioparticles by summarizing the physical principles behind the separation system and practical examples of biomedical applications. Full article
(This article belongs to the Special Issue Advances in Microfluidic Biosensing)
Show Figures

Figure 1

Back to TopTop