Special Issue "Smart Materials and Advanced Microsystems Technologies for Drug Delivery and Diagnostics"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 June 2022.

Special Issue Editors

Prof. Dr. Hongbo Zhang
E-Mail Website
Guest Editor
Pharmaceutical Sciences Laboratory and Turku Bioscience Center, Åbo Akademi University, 20520 Turku, Finland
Interests: nanomedicine; microfluidics; biomedical engineering
Prof. Dr. Yue-Zhou Zhang
E-Mail Website
Guest Editor
Frontiers Science Center for Flexible Electronics (FSCFE), Xi’an Institute of Flexible Electronics (IFE) and Xi’an Institute of Biomedical Materials & Engineering (IBME), Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China
Interests: nanoprecipitation based on microfluidics; synthetic medicinal chemistry; computer-aided drug design methods and applications; data mining for chemoinformatics
Prof. Sergey Filippov
E-Mail Website
Guest Editor
1. Faculty of Science and Engineering, Abo Akademi University, 20520 Turku, Finland
2. Department of Chemistry & Technology of Organic Materials, Polymers and Natural Compounds, AI-Faraby Kazakh National University, Almaty 050040, Kazakhstan
Interests: microfluidics

Special Issue Information

Dear Colleagues,

The smart materials and advanced microsystems technologies have greatly contributed to drug delivery and diagnostics fields. For example, different nano- and microparticles have been designed to deliver drugs, with smart features, including targeting, control release, theranostics etc.

Different advanced technologies, e.g. microfluidics, 3D printing, electrospinning etc. have been used to develop on site drug delivery and in vitro/in vivo diagnostic tools.

Different biomedical imaging tools have been used for advanced diagnostics etc.

In this special issue, we aim to collect the most recent applications of smart materials and advanced microsystems technologies in drug delivery and diagnostics. We are especially interested in the clinical and biomedical related applications that have a lead to future clinical and biomeical applications.

Prof. Dr. Hongbo Zhang
Prof. Dr. Yue-Zhou Zhang
Prof. Sergey Filippov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • diagnostic
  • smart materials
  • microsystems technologies
  • translational research

Published Papers (1 paper)

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Research

Article
A Smart Core-Crosslinked Supramolecular Drug Delivery System (SDDS) Enabled by Pendant Cyclodextrins Encapsulation of Drug Dimers via Host-Guest Interaction
Biosensors 2021, 11(9), 306; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11090306 - 30 Aug 2021
Viewed by 408
Abstract
Owing to poor aqueous solubility and low delivery efficiency, most of anti-cancer chemodrugs depend on various smart drug delivery platforms to enhance the treatment efficacy. Herein, a stimuli-responsive supramolecular drug delivery system (SDDS) is developed based on polymeric cyclodextrins (PCD) which crosslinked by [...] Read more.
Owing to poor aqueous solubility and low delivery efficiency, most of anti-cancer chemodrugs depend on various smart drug delivery platforms to enhance the treatment efficacy. Herein, a stimuli-responsive supramolecular drug delivery system (SDDS) is developed based on polymeric cyclodextrins (PCD) which crosslinked by stimuli-cleavable drug dimers via host-guest interaction. PEGylated PCD was precisely controlled synthesized by ring-opening polymerization and azide-alkyne click chemistry, and two doxorubicins (DOX) were linked with a disulfide bond to form a drug dimer (ss-DOX). They then co-assembled into supramolecular micelles. Drug dimers were utilized as cross-linkers to stabilize the micelles. The drug loading efficiency was very high that could be up to 98%. The size and morphology were measured by DLS and TEM. Owing to the disulfide bonds of drug dimers, these supramolecular micelles were dissociated by treating with dithiothreitol (DTT). In the meanwhile, the free DOXs were recovered and released from cavities of cyclodextrins because of dynamic equilibrium and hydrophilicity changes. The release profile was studied under mimic physiological conditions. Furthermore, in vitro cytotoxicity study showed excellent anti-cancer efficacy of reduced-responsive supramolecular polymeric micelles. Therefore, it can be served as a safe and stimuli-responsive SDDS for cancer therapy. Full article
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