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Biosensors
Special Issues
Optical Biosensors and Their Applications
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Optical Biosensors and Their Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 7343

Special Issue Editor

Prof. Dr. Anton Gaplovsky

E-Mail Website
Guest Editor
Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovičová 6, 84215 Bratislava 4, Slovakia
Interests: photochemistry; spectroscopy; functional materials

Special Issue Information

Dear Colleagues,

Chemical structures are capable of forming clusters by interaction, which by external stimuli (temperature, light, pH, etc.) change the physical properties of substances. So, using logical functions, the change of physical properties can be transformed into information that can be used as a data set for application purposes. When designing the architecture of molecular groupings of these materials, it is necessary to address issues related to the method of generating information at the molecular level. In most cases, the supramolecular unit consists of subunits, resp. "functional" molecules; therefore it is necessary to optimize their number, type, order of units, and also solve their mutual interconnection and coordination. New knowledge in the field of processes taking place in the cells of living organisms and their mechanisms, new knowledge in medicine and chemistry, and advances in the development of new technologies (e.g., nanotechnology, biotechnology, new light sources), together with smart applications and the current global pandemic, create the conditions and requirements for the development and improvement of optical biosensors. Optical biosensors thus achieve higher stability and specificity, higher sensitivity, reproducibility, and miniaturization, and a quick return on production costs.

This Special Issue focuses on publishing applications of the latest scientific knowledge in the field of optical biosensors, allowing mainly:

  1. Sensitive detection of a wide range of chemical compounds, including viruses, healthcare monitoring, drug screening, disease diagnosis and pollution control, etc.;
  2. New technical and technological solutions of optical biosensors;
  3. New specific and diagnostic applications of optical biosensors;
Prof. Dr. Anton Gaplovsky
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • optical fiber biosensors
  • single-molecule biosensors
  • biosensor chips
  • aptasensors
  • nanomaterials
  • transduction materials

Published Papers (2 papers)

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Research

9 pages, 2858 KiB  
Communication
Multiplexed, High-Sensitivity Measurements of Antibody Affinity Using Interferometric Reflectance Imaging Sensor
by Allison M. Marn, James Needham, Elisa Chiodi and M. Selim Ünlü
Biosensors 2021, 11(12), 483; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11120483 - 27 Nov 2021
Cited by 6 | Viewed by 3666
Abstract
Anthrax lethal factor (LF) is one of the enzymatic components of the anthrax toxin responsible for the pathogenic responses of the anthrax disease. The ability to screen multiplexed ligands against LF and subsequently estimate the effective kinetic rates (kon and [...] Read more.
Anthrax lethal factor (LF) is one of the enzymatic components of the anthrax toxin responsible for the pathogenic responses of the anthrax disease. The ability to screen multiplexed ligands against LF and subsequently estimate the effective kinetic rates (kon and koff) and complementary binding behavior provides critical information useful in diagnostic and therapeutic development for anthrax. Tools such as biolayer interferometry (BLI) and surface plasmon resonance imaging (SPRi) have been developed for this purpose; however, these tools suffer from limitations such as signal jumps when the solution in the chamber is switched or low sensitivity. Here, we present multiplexed antibody affinity measurements obtained by the interferometric reflectance imaging sensor (IRIS), a highly sensitive, label-free optical biosensor, whose stability, simplicity, and imaging modality overcomes many of the limitations of other multiplexed methods. We compare the multiplexed binding results obtained with the IRIS system using two ligands targeting the anthrax lethal factor (LF) against previously published results obtained with more traditional surface plasmon resonance (SPR), which showed consistent results, as well as kinetic information previously unattainable with SPR. Additional exemplary data demonstrating multiplexed binding and the corresponding complementary binding to sequentially injected ligands provides an additional layer of information immediately useful to the researcher. Full article
(This article belongs to the Special Issue Optical Biosensors and Their Applications)
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12 pages, 4571 KiB  
Communication
Polymer Optical Waveguide Grating-Based Biosensor to Detect Effective Drug Concentrations of Ginkgolide A for Inhibition of PMVEC Apoptosis
by Chunxue Wang, Pengfei Yi, Jiang Li, Haibing Dong, Changming Chen, Daming Zhang, Haiqing Shen and Bendong Fu
Biosensors 2021, 11(8), 264; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11080264 - 06 Aug 2021
Cited by 5 | Viewed by 2878
Abstract
In this work, we successfully developed a fluorinated cross-linked polymer Bragg waveguide grating-based optical biosensor to detect effective drug concentrations of ginkgolide A for the inhibition of pulmonary microvascular endothelial cell (PMVEC) apoptosis. Fluorinated photosensitive polymer SU-8 (FSU-8) as the sensing core layer [...] Read more.
In this work, we successfully developed a fluorinated cross-linked polymer Bragg waveguide grating-based optical biosensor to detect effective drug concentrations of ginkgolide A for the inhibition of pulmonary microvascular endothelial cell (PMVEC) apoptosis. Fluorinated photosensitive polymer SU-8 (FSU-8) as the sensing core layer and polymethyl methacrylate (PMMA) as the sensing window cladding were synthesized. The effective drug concentration range (5–10 µg/mL) of ginkgolide A for inhibition of PMVEC apoptosis was analyzed and obtained by pharmacological studies. The structure of the device was optimized to be designed and fabricated by direct UV writing technology. The properties of the biosensor were simulated with various refractive indices of different drug concentrations. The actual sensitivity of the biosensor was measured as 1606.2 nm/RIU. The resolution and detection limit were characterized as 0.05 nm and 3 × 10−5 RIU, respectively. The technique is suitable for safe and accurate detection of effective organic drug dosages of Chinese herbal ingredients. Full article
(This article belongs to the Special Issue Optical Biosensors and Their Applications)
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