SPR Biosensors for Medical Diagnostics, Environmental Monitoring, and Food Safety Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 16333

Special Issue Editors

Laboratory of Nano-photonics and Biosensors, Institute of Electro-Optical Engineering/ Department of Life Science, National Taiwan Normal University, Applied Science Building 3F, Inst. of Elec.-Opti. Eng., No. 88, Sec. 4, Ting-Chou Road, Wenshan Dist., Taipei 11677, Taiwan
Interests: optical biosensing; plasmonics; nanophotonics; organic optoelectronic devices integrated biosensor design; BioMEMS; optical system integration; advanced 2D materials synthesis and nanofabrication; DNA biosensors; microRNA biosensors; exosome biosensors
Special Issues, Collections and Topics in MDPI journals
1. Department of Nursing and Physiotherapy, University of León, 24071 León, Spain
2. Institute of Food Science and Technology (ICTAL), La Serna 58, 24007 León, Spain
Interests: biosensors; plasmonic sensors; surface plasmon resonance; localized surface plasmon resonance; biofunctionalization strategies; biomedical applications; clinical diagnostics; point of care
Special Issues, Collections and Topics in MDPI journals
Dept of Computer and Communication Systems Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 UPM Serdang, Seangor Darul Ehsan, Malaysia
Interests: optical sensors; optical microscopy and spectroscopy

Special Issue Information

Dear Colleagues,

I am very pleased to invite you to contribute to this Special Issue on SPR Biosensors, which are emerging research subjects with various applications, from the biomedical field (from early diagnosis to therapy monitoring) to food quality control and environmental analyses.

Plasmonic biosensors for biomedical applications are receiving increasing attention in scientific communities. Substituting existing bulky and expensive instrumentation with smart sensors having a reduced size and lower cost analysis systems, lab-on-a-chip, or paper-based devices is a challenge from the perspective of precision medicine, point of care analyses, and personalized pharmacological treatment.

Therefore, the rapid developments that have occurred in SPR biosensors, concepts in structural design, fabrication techniques, sensing materials, numerical simulation, gas sensing, and diagnostic applications are contributing to significantly progressing accurate and highly sensitive detection in future clinical applications.

Manuscripts presenting comprehensive reviews for the detailed analysis of sensor performance characteristics are welcome to showcase the current trends and challenges in SPR biosensing.

Scope of the Special Issue:

New biosensor solutions applied in SPR;
Nanotechnology and novel materials applied to gas sensors and biosensors;
Novel instrumentation systems for SPR biosensors;
Novel sensing techniques for SPR biosensors;
New methodology approaches in the use of advanced data processing methods;
Application of SPR in biomedical applications;
Application of SPR in environmental monitoring.

This Special Issue plans not only to provide an overview of recent achievements but also to stimulate ideas about the current and future research in the SPR sensor field. Both original papers and reviews are welcome.

Prof. Dr. Nan-Fu Chiu
Prof. Dr. Elba Mauriz
Prof. Dr. Ahmad Shukri Muhammad Noor
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Plasmonic
  • Surface plasmon resonance (SPR)
  • Localized surface plasmon resonance (LSPR)
  • SPR biosensors
  • Sensing materials
  • SPR signal enhancement
  • Gas sensing
  • Food safety
  • Environmental monitoring
  • Diagnostic applications

Published Papers (5 papers)

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Editorial

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4 pages, 209 KiB  
Editorial
The Current Status and Future Promise of SPR Biosensors
by Nan-Fu Chiu
Biosensors 2022, 12(11), 933; https://0-doi-org.brum.beds.ac.uk/10.3390/bios12110933 - 27 Oct 2022
Cited by 7 | Viewed by 1833
Abstract
The most commonly used protein detection methods in clinical diagnosis and disease monitoring are enzyme-linked immunosorbent assay (ELISA), Western blotting (immunoblot), and lateral flow assay (LFA) rapid screening, of which ELISA is the gold standard immunoassay in clinical practice [...] Full article

Research

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10 pages, 1851 KiB  
Communication
Surface Plasmon Resonance Biosensors with Magnetic Sandwich Hybrids for Signal Amplification
by Ting Sun, Mengyao Li, Feng Zhao and Lin Liu
Biosensors 2022, 12(8), 554; https://0-doi-org.brum.beds.ac.uk/10.3390/bios12080554 - 22 Jul 2022
Cited by 6 | Viewed by 1578
Abstract
The conventional signal amplification strategies for surface plasmon resonance (SPR) biosensors involve the immobilization of receptors, the capture of target analytes and their recognition by signal reporters. Such strategies work at the expense of simplicity, rapidity and real-time measurement of SPR biosensors. Herein, [...] Read more.
The conventional signal amplification strategies for surface plasmon resonance (SPR) biosensors involve the immobilization of receptors, the capture of target analytes and their recognition by signal reporters. Such strategies work at the expense of simplicity, rapidity and real-time measurement of SPR biosensors. Herein, we proposed a one-step, real-time method for the design of SPR biosensors by integrating magnetic preconcentration and separation. The target analytes were captured by the receptor-modified magnetic nanoparticles (MNPs), and then the biotinylated recognition elements were attached to the analyte-bound MNPs to form a sandwich structure. The sandwich hybrids were directly delivered to the neutravidin-modified SPR fluidic channel. The MNPs hybrids were captured by the chip through the neutravidin–biotin interaction, resulting in an enhanced SPR signal. Two SPR biosensors have been constructed for the detection of target DNA and beta-amyloid peptides with high sensitivity and selectivity. This work, integrating the advantages of one-step, real-time detection, multiple signal amplification and magnetic preconcentration, should be valuable for the detection of small molecules and ultra-low concentrations of analytes. Full article
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13 pages, 2296 KiB  
Article
Rapid Detection of Virus Nucleic Acid via Isothermal Amplification on Plasmonic Enhanced Digitizing Biosensor
by Shih-Chung Wei, Chia-Chen Chang, Tsung-Liang Chuang, Kung-Bin Sung and Chii-Wann Lin
Biosensors 2022, 12(2), 75; https://0-doi-org.brum.beds.ac.uk/10.3390/bios12020075 - 28 Jan 2022
Cited by 3 | Viewed by 2505
Abstract
Rapid detection for infectious diseases is highly demanded in diagnosis and infection prevention. In this work, we introduced a plasmonic enhanced digitizing biosensor for the rapid detection of nucleic acids. The sensor successfully achieved the detection of loop-mediated isothermal amplification for the hepatitis [...] Read more.
Rapid detection for infectious diseases is highly demanded in diagnosis and infection prevention. In this work, we introduced a plasmonic enhanced digitizing biosensor for the rapid detection of nucleic acids. The sensor successfully achieved the detection of loop-mediated isothermal amplification for the hepatitis virus in this work. The sensor comprised a nanodisc array and Bst polymerases conjugated on the rough surface of a nanodisc. The rough surface of the nanodisc provided plasmonic hot spots to enhance the fluorescence signal. The virus DNA was detected by conducting a modified loop-mediated isothermal amplification with fluorescence resonance energy transfer reporter conjugated primers on the sensor. The modified isothermal amplification improved the signal contrast and detection time compared to the original assay. By integrating the modified amplification assay and plasmonic enhancement sensor, we achieved rapid detection of the hepatitis virus. Nucleic acid with a concentration of 10−3 to 10−4 mg/mL was detected within a few minutes by our design. Our digitizing plasmonic nanoarray biosensor also showed 20–30 min earlier detection compared to conventional loop-mediated isothermal amplification sensors. Full article
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12 pages, 1455 KiB  
Article
SPR Analysis of SUMO-Murine Rap1-Interacting Factor 1 C-Terminal Domain Interaction with G4
by Sana Alavi, Hamed Ghadiri, Bahareh Dabirmanesh and Khosro Khajeh
Biosensors 2022, 12(1), 37; https://0-doi-org.brum.beds.ac.uk/10.3390/bios12010037 - 12 Jan 2022
Cited by 3 | Viewed by 1809
Abstract
One of the advantages of surface plasmon resonance is its sensitivity and real-time analyses performed by this method. These characteristics allow us to further investigate the interactions of challenging proteins like Rap1-interacting factor 1 (Rif1). Rif1 is a crucial protein responsible for regulating [...] Read more.
One of the advantages of surface plasmon resonance is its sensitivity and real-time analyses performed by this method. These characteristics allow us to further investigate the interactions of challenging proteins like Rap1-interacting factor 1 (Rif1). Rif1 is a crucial protein responsible for regulating different cellular processes including DNA replication, repair, and transcription. Mammalian Rif1 is yet to be fully characterized, partly because it is predicted to be intrinsically disordered for a large portion of its polypeptide. This protein has recently been the target of research as a potential biomarker in many cancers. Therefore, finding its most potent interacting partner is of utmost importance. Previous studies showed Rif1’s affinity towards structured DNAs and amongst them, T6G24 was superior. Recent studies have shown mouse Rif1 (muRif1) C-terminal domain’s (CTD) role in binding to G-quadruplexes (G4). There were many concerns in investigating the Rif1 and G4 interaction, which can be minimized using SPR. Therefore, for the first time, we have assessed its binding with G4 at nano-molar concentrations with SPR which seems to be crucial for its binding analyses. Our results indicate that muRif1-CTD has a high affinity for this G4 sequence as it shows a very low KD (6 ± 1 nM). Full article
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Review

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21 pages, 4803 KiB  
Review
Recent Advancements in Aptamer-Based Surface Plasmon Resonance Biosensing Strategies
by Chia-Chen Chang
Biosensors 2021, 11(7), 233; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11070233 - 10 Jul 2021
Cited by 37 | Viewed by 6567
Abstract
Surface plasmon resonance (SPR) can track molecular interactions in real time, and is a powerful as well as widely used biological and chemical sensing technique. Among the different SPR-based sensing applications, aptamer-based SPR biosensors have attracted significant attention because of their simplicity, feasibility, [...] Read more.
Surface plasmon resonance (SPR) can track molecular interactions in real time, and is a powerful as well as widely used biological and chemical sensing technique. Among the different SPR-based sensing applications, aptamer-based SPR biosensors have attracted significant attention because of their simplicity, feasibility, and low cost for target detection. Continuous developments in SPR aptasensing research have led to the emergence of abundant technical and design concepts. To understand the recent advances in SPR for biosensing, this paper reviews SPR-based research from the last seven years based on different sensing-type strategies and sub-directions. The characteristics of various SPR-based applications are introduced. We hope that this review will guide the development of SPR aptamer sensors for healthcare. Full article
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