Special Issue "Autoantibodies in Infection-Associated Cognitive Deficit: Pathogenic Mechanisms, Clinical Aspects, and Therapeutic Approaches"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: 15 May 2022.

Special Issue Editors

Dr. Guglielmo Lucchese
E-Mail Website
Guest Editor
Department of Neurology, University Medicine Greifswald, 17489 Greifswald, Germany
Interests: cognitive neuroinfectiology; humoral immunity; human electrophysiology
Dr. Antje Vogelgesang
E-Mail Website
Guest Editor
Department of Neurology, University of Greifswald, 17489 Greifswald, Germany
Interests: neuroimmunology; post stroke immune alterations; stroke and Alzheimer’s disease models; immune system and cognition

Special Issue Information

Dear Colleagues,

Recent global events have reminded us that the impact of infections on cognitive abilities is a key aspect of the host–pathogen interaction (Dunn et al. 2005; Benros et al., 2015). Indeed, the current pandemic appears to be the prelude to a long-term increase in cognitive and neuropsychiatric deficits (de Erausquin et al., 2021) and the new coronavirus disease highlights the crucial importance of elucidating possible mechanistic links between infections and cognitive functions (Troyer et al., 2020) in order to develop effective and precise interventions. Not just viruses, but also bacteria and parasites are associated with cognitive deterioration.

The immune system is a key player in the interaction between pathogens and the human brain. Specifically, autoantibody production in association with infection appears to bear pathogenic potential for cognitive impairment. Molecular mimicry, among other mechanisms, has been proposed to mediate such autoimmune phenomena. However, a detailed mechanistic account of autoantibody-mediated para-/post-infective neuronal and cognitive damage is still missing.

Moreover, if and how anti-neuronal antibodies can affect specific cognitive functions like memory, language, and attention is largely unknown. Bridging the gap between the molecular immunology of infection-induced autoimmunity and cognitive neurology would result in better diagnostic and therapeutic procedures.

With the present call, we intend to collect the most recent evidence on:

  • Biological and molecular mechanisms originating autoantibodies targeting the brain during and after infections;
  • Pathogenic effects exerted by anti-neuronal autoantibodies at the molecular level (not necessarily limited to post-infectious etiology);
  • Neuropsychological patterns of cognitive deficits associated with specific microbes and/or autoantibodies;
  • Neuroimaging and functional indexes of cognition in para-/post-infectious autoimmunity.

Dr. Guglielmo Lucchese
Dr. Antje Vogelgesang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • autoantibodies
  • cognition
  • infections
  • autoimmunity

Published Papers

This special issue is now open for submission.
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