The Brain Imaging Replication Crisis

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: closed (30 August 2022) | Viewed by 5380

Special Issue Editor


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Guest Editor
Clinical Psychiatry, Weill Cornell Medical College, White Plains, NY 10605, USA
Interests: adult psychiatry; geriatric psychiatry; mood disorders; brain fMRI; brain functional connectivity; visual inspection of independent components; dual regression

Special Issue Information

Dear Colleagues,

Evidence-based medicine and all scientific advancements depend on the ability to replicate scientific findings. Some irreplicable results are expected in the course of the scientific evaluation supported by statistical testing, for example, with the conventional α = 0.05. However, current evidence indicates that actual rates of non-replication across a wide variety of scientific endeavors are much higher than 0.05—a problem known as the replication crisis.  Factors that can contribute to this problem include academic and financial incentives; publication practices; limitations in the sensitivity and reliability of scientific tests; “p-hacking” and “HARKing” that inflate effective p-values for experiments; methodological errors. The replication crisis significantly impacts the field of brain imaging, despite of and perhaps because of the methodological complexity involved with this field. The severity of the problem is a subject of much discussion and debate, but the problem remains largely unsolved, with the potential to seriously impede scientific progress.

This Special Issue is a forum for ideas concerning the replication crisis as it applies to brain imaging. Welcome are summaries and short communications concerning the problem and existing solutions, as well as original research papers with new ideas for how to address it.  Such papers could include descriptions of improved methods, openly available tools, or attempts to replicate previous studies.

Dr. Robert Emmett Kelly
Guest Editor

Manuscript Submission Information

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Keywords

  • brain imaging
  • replication crisis
  • reproducibility
  • irreplicable results
  • open science
  • evidence-based medicine
  • publication bias
  • academic incentives
  • p-hacking
  • HARKing

Published Papers (2 papers)

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Editorial

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4 pages, 220 KiB  
Editorial
Replicability in Brain Imaging
by Robert E. Kelly, Jr. and Matthew J. Hoptman
Brain Sci. 2022, 12(3), 397; https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci12030397 - 16 Mar 2022
Cited by 3 | Viewed by 2199
Abstract
In the early 2010s, the “replication crisis” and synonymous terms (“replicability crisis” and “reproducibility crisis”) were coined to describe growing concerns regarding published research results too often not being replicable, potentially undermining scientific progress [...] Full article
(This article belongs to the Special Issue The Brain Imaging Replication Crisis)

Research

Jump to: Editorial

20 pages, 791 KiB  
Article
Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study
by Donato Liloia, Annachiara Crocetta, Franco Cauda, Sergio Duca, Tommaso Costa and Jordi Manuello
Brain Sci. 2022, 12(10), 1367; https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci12101367 - 09 Oct 2022
Cited by 7 | Viewed by 2058
Abstract
The present work is a replication article based on the paper “Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies” by McGrath and Stoodley (2019). In the original research, the authors used activation likelihood estimation (ALE), a [...] Read more.
The present work is a replication article based on the paper “Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies” by McGrath and Stoodley (2019). In the original research, the authors used activation likelihood estimation (ALE), a technique to perform coordinate-based meta-analysis (CBMA), to investigate the existence of brain regions undergoing gray matter alteration in association with both attention-deficit/hyper-activity disorder (ADHD) and dyslexia. Here, the same voxel-based morphometry dataset was analyzed, while using the permutation-subject images version of signed differential mapping (PSI-SDM) in place of ALE. Overall, the replication converged with the original paper in showing a limited overlap between the two conditions. In particular, no significant effect was found for dyslexia, therefore precluding any form of comparison between the two disorders. The possible influences of biological sex, age, and medication status were also ruled out. Our findings are in line with literature about gray matter alteration associated with ADHD and dyslexia, often showing conflicting results. Therefore, although neuropsychological and clinical evidence suggest some convergence between ADHD and dyslexia, more future research is sorely needed to reach a consensus on the neuroimaging domain in terms of patterns of gray matter alteration. Full article
(This article belongs to the Special Issue The Brain Imaging Replication Crisis)
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