Cellular and Molecular Mechanisms of Brain Aging

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 520

Special Issue Editors

Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy
Interests: neural development; neural stem cells; neurogenesis; aging; gene regulation; morphogens; homeobox genes
Special Issues, Collections and Topics in MDPI journals
Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy
Interests: neurodegeneration; neuronal cell death and stress; endoplasmic reticulum stress; protein aggregation; misfolded protein diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aging is associated with cognitive decline and with increased susceptibility to neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, among others. The increasing life expectancy of the human population may result in large numbers of cognitively impaired elderly subjects, with a heavy burden on healthcare systems and huge social and financial challenges. The development of therapeutic approaches to mitigate the effects of aging on brain health and cognitive functions require a comprehensive knowledge of the age-related alterations to brain neuronal networks and the underlying mechanisms, which is still lacking. Furthermore, age-associated neuropathological conditions may involve an enhancement of the mechanisms driving physiological brain aging, a dysregulation of the protective mechanisms active in the aging brain, or both. Therefore, it is crucial to compare the alterations, and the mechanisms, implicated in physiological and pathological brain aging, and to identify common and diverging traits. This Special Issue is focused on the cellular and molecular alterations taking place during physiological and/or pathological brain aging, and on the elucidation of the mechanisms driving them. Submission of both original research articles and of review articles providing a critical discussion of recent progress in the field are welcome. Original research manuscripts providing mechanistic insights based on functional data are preferred, but descriptive studies will also be considered, as long as they do not duplicate previously published work.

Dr. Giuseppe Lupo
Dr. Maria Elena Miranda Banos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuronal death
  • neuronal dysfunction
  • neuroinflammation
  • astrocytes
  • microglia
  • brain vasculature
  • gene expression
  • protein folding and trafficking
  • cell signaling

Published Papers

There is no accepted submissions to this special issue at this moment.
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