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Brain Sciences
Special Issues
Migraine and Sex Hormones
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Migraine and Sex Hormones

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuroscience of Pain".

Deadline for manuscript submissions: closed (10 February 2022) | Viewed by 5204

Special Issue Editors

Prof. Dr. Gabriele S. Merki-Feld

E-Mail Website
Guest Editor
Reproductive Endocrinology Clinic, University Hospital Zurich, 8091 Zurich, Switzerland
Interests: hormonal contraception and it's benefits and risks; management of adverse events in women using contraception; migraine in women; benefits of progestin-only contraceptive methods; treatment of negative moods associated with migraine; hormonal treatment of endometriosis as a comorbidity of migraine; intrauterine contraception
Dr. Raffaele Ornello

E-Mail Website
Guest Editor
Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, 67100 L'Aquila, Italy
Interests: migraine treatment; comorbidities of migraine; epidemiology of stroke
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Migraine is usually regarded as a female disorder; however, the reasons for the higher prevalence of migraines in women than in men are not fully known. Sex hormones could play an important role in the pathophysiology and treatment of migraines. Specific clinical entities, such as menstrual migraine, are strongly influenced by female sex hormones, while the role of male sex hormones in migraines is unclear. Our Special Issue aims to summarize the most recent insights into the relationship between migraines and sex hormones, to help inform clinical practice and design new research on the unanswered questions. We are soliciting review papers that cover the different aspects of the topic, including basic and clinical research.

Prof. Dr. Gabriele S. Merki-Feld
Dr. Raffaele Ornello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • migraine
  • estrogen
  • progestin
  • gender
  • hormones
  • menstruation
  • menopause

Published Papers (2 papers)

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11 pages, 271 KiB  
Article
Dealing with Headache: Sex Differences in the Burden of Migraine- and Tension-Type Headache
by Maria Susanne Neumeier, Heiko Pohl, Peter S. Sandor, Hans Gut, Gabriele S. Merki-Feld and Colette Andrée
Brain Sci. 2021, 11(10), 1323; https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci11101323 - 05 Oct 2021
Cited by 10 | Viewed by 2121
Abstract
Objective: The aim of this study was to investigate sex differences in the burden of migraine and tension-type headache (TTH). Background: Migraine and TTH are more common in women than in men, with differences in comorbidities, treatment responses, disease-modifying factors, and ictal and [...] Read more.
Objective: The aim of this study was to investigate sex differences in the burden of migraine and tension-type headache (TTH). Background: Migraine and TTH are more common in women than in men, with differences in comorbidities, treatment responses, disease-modifying factors, and ictal and interictal burden of disease. Information about sex-related influences on ictal and interictal burden is limited, and an increased understanding is mandatory to provide tailored individual treatment for female and male patients. Methods: Participants answered an online survey based on the EUROLIGHT questionnaire. Inclusion criteria were the consent to participate, complete responses to the diagnostic questions, and information about their sex. Sex differences were investigated using the Mann–Whitney U test or Chi-square test. For detecting factors that influence the burden of disease, we built binary regression models. Results: We included 472 (74.6% female) migraineurs and 161 (59.6% female) participants with TTH. Women with migraine reported significantly more problems in their love lives, more self-concealment, less feelings of being understood by family and friends, more interictal anxiety, a higher pain severity, and more depression and anxiety symptoms than men. For TTH, we did not find significant sex-related differences. A higher headache frequency was the factor that increased the burden of disease in female but not in male migraneurs. Conclusion: The burden of disease was higher in women than men with migraine in many aspects, but not with TTH. Therefore, according to our results, there is a need for sex-specific precision medicine for migraine but not TTH. Controlling the headache frequency with a proper acute or prophylactic treatment and treating comorbid depression and anxiety symptoms is crucial to ease migraine’s burden, especially in women. Full article
(This article belongs to the Special Issue Migraine and Sex Hormones)

Other

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29 pages, 1959 KiB  
Systematic Review
Has the Phase of the Menstrual Cycle Been Considered in Studies Investigating Pressure Pain Sensitivity in Migraine and Tension-Type Headache: A Scoping Review
by Francisca Curiel-Montero, Francisco Alburquerque-Sendín, César Fernández-de-las-Peñas and Daiana P. Rodrigues-de-Souza
Brain Sci. 2021, 11(9), 1251; https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci11091251 - 21 Sep 2021
Cited by 5 | Viewed by 2532
Abstract
Objective: The aim of this scoping review was to identify if the phase of the menstrual cycle was considered in observational studies comparing pressure pain sensitivity between women with migraine or tension-type headache (TTH) and headache-free women. Methods: A systematic electronic literature search [...] Read more.
Objective: The aim of this scoping review was to identify if the phase of the menstrual cycle was considered in observational studies comparing pressure pain sensitivity between women with migraine or tension-type headache (TTH) and headache-free women. Methods: A systematic electronic literature search in PubMed, Medline, Web of Science, Scopus, and CINAHL databases was conducted. Observational studies including one or more groups with TTH and/or migraine comparing pressure pain thresholds (PPTs) were included. The methodological quality (risk of bias) was assessed with the Newcastle-Ottawa Scale. Authors, objectives, inclusion/exclusion criteria, size sample, female sample, tool to assess PPTs, mean age, and the use of any medication were extracted and analyzed independently by two authors. Results: From a total of 1404 and 1832 identified articles for TTH and migraine, 30 and 18 studies satisfied the criteria and were included. Nineteen (63.4%) studies assessing TTH patients and eleven (61.1%) assessing migraine patients showed a high risk of bias. The most common flaws were attributed to improper selection of control and control over other additional factors. Based on the systematic review, just one study including TTH and one including migraine patients considered the menstrual cycle. Conclusion: The results of this scoping review identified that the phase of the menstrual cycle has been rarely considered in studies investigating sensitivity to pressure pain in primary headaches, such as TTH or migraine, although there is evidence showing the relevance of the phase of the menstrual cycle in pain perception. Full article
(This article belongs to the Special Issue Migraine and Sex Hormones)
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