Degenerative Cerebellar Ataxias: Unrevealing Pathogenesis to Trace Novel Effective Therapeutic Pathways

Dear Colleagues,

Degenerative cerebellar ataxias (dCA) are a group of rare, clinically and genetically heterogeneous neurological disorders whose main symptoms are impaired balance and motor coordination, caused by a slowly progressive degeneration of cerebellar neurons and related neuroanatomical structures.

dCA can be also sporadic, and a minority of such cases also recognizes a specific genetic etiology. In the last few years, the use of NGS technologies has been leading to significant progresses in the research field of dCA, unrevealing a pathogenic complexity, but also identifying few specific functional hubs to which converge the many various dCA–related genes

This exciting research field is still ongoing, and this Special Issue focused on dCA, aims to include novel clinical and basic research studies or updated reviews either concerning further phenotypic and pathogenic characterization of dCA, or reporting on innovative therapeutic options as well as more sensitive outcome measures useful for upcoming human clinical trials.

Dr. Gabriella Silvestri
Guest Editor

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