Special Issue "Cell-Cell Communication and Extracellular Vesicles in Cancer"

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 31 May 2022.

Special Issue Editors

Dr. Kebin Hu
E-Mail Website
Guest Editor
Department of Medicine and Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Interests: cell death and proliferation; signal transduction; inflammation; fibrosis; and kidney injury and repair
Dr. Yandong Zhou
E-Mail Website
Guest Editor
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Interests: cell-cell communication; Orai channels
Dr. Ling Lin
E-Mail Website
Guest Editor
Department of Medicine, Division of Nephrology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Interests: cell-cell communication; integrin signal pathway; NF-κB signaling pathway

Special Issue Information

Dear Colleague,

Cell–cell communication, either through direct contact or indirectly, is critical for multiple cellular processes, such as proliferation, survival, differentiation, and transdifferentiation, and plays a fundamental role in maintaining the integrity of tissue structure and the cellular environment. Extracellular vesicles (EVs) are a group of nanosized lipid-bound vesicles derived from various cellular origins that play a key role in cell–cell communication. EV-mediated cell–cell communication is involved in multiple processes of tumorigenesis and metastasis. It not only affects tumor growth, metabolism, and survival but also facilitates the surrounding or distant non-tumor cells to form a protumor microenvironment. Notably, recent studies indicate that EVs have the potential to serve as a next-generation drug delivery platform for cancer treatment.

We invite authors to contribute original research articles, as well as review articles, of both in vitro and in vivo studies using animal and human models to this Special Issue on the mechanisms of cell–cell communication and EV-mediated tumorigenesis, metastasis, and antitumor treatment.

Dr. Kebin Hu
Dr. Yandong Zhou
Dr. Ling Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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Article
Exploration of Extracellular Vesicle miRNAs, Targeted mRNAs and Pathways in Prostate Cancer: Relation to Disease Status and Progression
Cancers 2022, 14(3), 532; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14030532 (registering DOI) - 21 Jan 2022
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Abstract
Background: Prostate cancer (PCa) lacks non-invasive specific biomarkers for aggressive disease. We studied the potential of urinary extracellular vesicles (uEV) as a liquid PCa biopsy by focusing on the micro RNA (miRNA) cargo, target messenger (mRNA) and pathway analysis. Methods: We subjected uEV [...] Read more.
Background: Prostate cancer (PCa) lacks non-invasive specific biomarkers for aggressive disease. We studied the potential of urinary extracellular vesicles (uEV) as a liquid PCa biopsy by focusing on the micro RNA (miRNA) cargo, target messenger (mRNA) and pathway analysis. Methods: We subjected uEV samples from 31 PCa patients (pre-prostatectomy) to miRNA sequencing and matched uEV and plasma EV (pEV) from three PCa patients to mRNA sequencing. EV quality control was performed by electron microscopy, Western blotting and particle and RNA analysis. We compared miRNA expression based on PCa status (Gleason Score) and progression (post-prostatectomy follow-up) and confirmed selected miRNAs by quantitative PCR. Expression of target mRNAs was mapped in matched EV. Results: Quality control showed typical small uEV, pEV, RNA and EV-protein marker enriched samples. Comparisons between PCa groups revealed mostly unique differentially expressed miRNAs. However, they targeted comprehensive and largely overlapping sets of cancer and progression-associated signalling, resistance, hormonal and immune pathways. Quantitative PCR confirmed changes in miR-892a (Gleason Score 7 vs. ≥8), miR-223-3p (progression vs. no progression) and miR-146a-5p (both comparisons). Their target mRNAs were expressed widely in PCa EV. Conclusions: PCa status and progression-linked RNAs in uEV are worth exploration in large personalized medicine trials. Full article
(This article belongs to the Special Issue Cell-Cell Communication and Extracellular Vesicles in Cancer)
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Review

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Review
Perineural Invasion and Associated Pain Transmission in Pancreatic Cancer
Cancers 2021, 13(18), 4594; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers13184594 - 13 Sep 2021
Viewed by 693
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the cancers with the highest incidence of perineural invasion (PNI), which often indicates a poor prognosis. Aggressive tumor cells invade nerves, causing neurogenic inflammation; the tumor microenvironment also induces nerves to undergo a series of structural [...] Read more.
Pancreatic ductal adenocarcinoma (PDAC) is one of the cancers with the highest incidence of perineural invasion (PNI), which often indicates a poor prognosis. Aggressive tumor cells invade nerves, causing neurogenic inflammation; the tumor microenvironment also induces nerves to undergo a series of structural and functional reprogramming. In turn, neurons and the surrounding glial cells promote the development of pancreatic cancer through autocrine and/or paracrine signaling. In addition, hyperalgesia in PDAC patients implies alterations of pain transmission in the peripheral and central nervous systems. Currently, the studies on this topic are relatively limited. This review will elaborate on the mechanisms of tumor–neural interactions and its possible relationship with pain from several aspects that have been focused on in recent years. Full article
(This article belongs to the Special Issue Cell-Cell Communication and Extracellular Vesicles in Cancer)
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