Dear Colleagues,

We are delighted to present this Special Issue, which will address the important topic “Impact of Cancer Cachexia on Cardiac and Skeletal Muscle: Role of Exercise Training”. It is well known that cancer results in cardiac and skeletal muscle atrophy, which severely affects function and quality of life. However, the interaction between cancer and the onset of striated muscle atrophy at the physiological, cellular, and molecular levels remains poorly understood, with limited therapeutic approaches firmly established. In particular, while evidence indicates that cancer can induce both cardiac and skeletal muscle remodeling, whether this occurs at a similar rate and is mediated by the same or distinct signaling pathways is poorly explored.

One of the most effective interventions for attenuating cancer cachexia is exercise training. While we now understand the broad benefits associated with exercise in cancer, we still have a poor understanding of the underlying mechanisms involved at the molecular level. Improved knowledge of how exercise modulates key signaling pathways involved in muscle atrophy/hypertrophy such as the ubiquitin proteasome and autophagy-lysosome systems will be important for developing drug targets that may be beneficial for patients in whom physical exertion is not possible. In this Special Issue, we invite investigators to contribute narrative reviews or original research articles. Articles should improve our understanding of how exercise counters the effects of cancer-related skeletal and/or cardiac muscle atrophy. Potential topics include but are not limited to the cellular and molecular mechanisms by which exercise regulate:

• Immunological, inflammatory, and redox processes;
• Anabolic and catabolic signaling, including their crosstalk;
• Energy balance and metabolic homeostasis;
• Interaction between cancer and cardiac failure.

Collectively, we aim to better understand the underlying mechanisms involved in cancer cachexia alongside identifying potential drug targets of the future.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• atrophy
• cachexia
• cancer
• cardiac muscle
• exercise
• heart failure
• skeletal muscle
• risk factors