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Cancers
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Cancer Cell Metabolism, Glycolysis, Lactate Production and Transport and Potential...
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Cancer Cell Metabolism, Glycolysis, Lactate Production and Transport and Potential Therapeutic Options for Inhibitors

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (1 November 2022) | Viewed by 4488

Special Issue Editor

Prof. Dr. Christopher J. Rivard

E-Mail Website
Guest Editor
Division of Medical Oncology, University of Colorado Denver, Aurora, CO 80045, USA
Interests: cancer biomarkers; immune checkpoints; humanized mouse models; glycolysis as driver for oncogene expression

Special Issue Information

Dear Colleague,

Glucose conversion to lactate in cancer cells is a hallmark of accelerated glucose consumption and growth rate as described almost a century ago by Otto Warburg. More recently, research has identified that increased glycolysis in cancer cells leads to enhanced cellular lactate and increased lactate export to the tumor microenvironment, resulting in a lower pH. Increased cellular lactate accumulation has been shown to increase oncogene expression, leading to reprogramming of cellular metabolism toward glycolysis as opposed to mitochondrial oxidative phosphorylation, known as the “lactogenesis hypothesis”. Potential drugs focused on blunting glycolysis in cancer cells may reduce cellular growth rates, increase sensitivity to anticancer drugs, and provide an additional tool to oncologists in their therapy arsenal. 

Prof. Dr. Christopher J. Rivard
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glycolysis
  • lactate production
  • lactate dehydrogenase
  • metabolomics
  • cancer cell biology
  • Warburg effect
  • LDH inhibitors
  • cellular lactate transporters
  • tumor microenvironment

Published Papers (2 papers)

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Research

14 pages, 7825 KiB  
Article
Pim-2 Kinase Regulates Energy Metabolism in Multiple Myeloma
by Zhaoyun Liu, Yixuan Guo, Xiaohan Liu, Panpan Cao, Hui Liu, Xifeng Dong, Kai Ding and Rong Fu
Cancers 2023, 15(1), 67; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers15010067 - 22 Dec 2022
Cited by 2 | Viewed by 1461
Abstract
Pim-2 kinase is overexpressed in multiple myeloma (MM) and is associated with poor prognosis in patients with MM. Changes in quantitative metabolism, glycolysis, and oxidative phosphorylation pathways are reportedly markers of all tumor cells. However, the relationship between Pim-2 and glycolysis in MM [...] Read more.
Pim-2 kinase is overexpressed in multiple myeloma (MM) and is associated with poor prognosis in patients with MM. Changes in quantitative metabolism, glycolysis, and oxidative phosphorylation pathways are reportedly markers of all tumor cells. However, the relationship between Pim-2 and glycolysis in MM cells remains unclear. In the present study, we explored the relationship between Pim-2 and glycolysis. We found that Pim-2 inhibitors inhibited glycolysis and energy production in MM cells. Inhibition of Pim-2 decreased the proliferation of MM tumor cells and increased their susceptibility to apoptosis. Our data suggest that reduced Pim-2 expression inhibits the energy metabolism process in MM, thereby inhibiting tumor progression. Hence, Pim-2 is a potential metabolic target for MM treatment. Full article
(This article belongs to the Special Issue Cancer Cell Metabolism, Glycolysis, Lactate Production and Transport and Potential Therapeutic Options for Inhibitors)
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17 pages, 4009 KiB  
Article
Pathological Significance of GLUT-1 Expression in Breast Cancer Cells in Diabetic and Obese Patients: The French Guiana Study
by Valentin Suteau, John Bukasa-Kakamba, Beatrice Virjogh-Cenciu, Antoine Adenis, Nadia Sabbah and Kinan Drak Alsibai
Cancers 2022, 14(2), 437; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14020437 - 16 Jan 2022
Cited by 3 | Viewed by 2271
Abstract
The prevalence of obesity and type 2 diabetes is higher in French Guiana compared to mainland France. These metabolic disorders are associated with an increased risk of cancer. One of the factors involved is hyperinsulinemia that promotes the action of glucose transporter 1 [...] Read more.
The prevalence of obesity and type 2 diabetes is higher in French Guiana compared to mainland France. These metabolic disorders are associated with an increased risk of cancer. One of the factors involved is hyperinsulinemia that promotes the action of glucose transporter 1 (GLUT-1). The objective of this study is to characterize the expression of GLUT-1 in breast cancers cells in diabetic and obese patients compared to those who are not and to describe the clinical and histological prognostic factors of breast cancer in this population. We conducted a monocentric study including patients with breast cancer diagnosed between 2014 and 2020. Patients were classified into three groups: diabetes, obesity, and control group. The GLUT-1 expression was assessed by immunohistochemistry. In total, 199 patients were included in this study. The median age was 53.5 years, and the median tumor size was 2.8 cm. Luminal A was the most frequent molecular type (58.1%), followed by the triple-negative type (19.9%). The breast cancer in our population was characterized by a younger age at diagnosis, more aggressive molecular types, and larger tumor size. Thus, we suggest the advancement of the age of breast cancer screening in this territory. A total of 144 patients (31 diabetes, 22 obese, and 91 control group) were included for the study of GLUT-1 expression. Overexpression of GLUT-1 was observed in 60.4% of cases and in all carcinoma in situ lesions. GLUT-1 overexpression was associated with more aggressive cancers. This overexpression is correlated with high histological grade, high proliferation index, and aggressive molecular types. Our study found no difference in GLUT-1 expression between the diabetic or obese patients and the control group. These results highlight the potential role of GLUT-1 as a tumor metabolic prognostic marker and also as an interesting target therapy, independently of patient metabolic disorder. Full article
(This article belongs to the Special Issue Cancer Cell Metabolism, Glycolysis, Lactate Production and Transport and Potential Therapeutic Options for Inhibitors)
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