Extracellular Vesicle in Cancer Biology
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 9672
Special Issue Editors
2. Division of Surgical On-cology, Department of Surgery, Wexner Medical Center, The Ohio State University, 410W 10th Ave., Columbus, OH 43210, USA
Interests: extracellular vesicles; exosomes; microenvironment; adipose microenvironment; sarcoma; liposarcoma; lncRNAs; miRNAs
Interests: extracellular vesicles; tumor microenvironment; microRNAs; cancer genetics; cancer-associated cachexia
Special Issue Information
Dear Colleagues,
Extracellular vesicles (EVs) consist of a very heterogeneous group of small, membrane-derived particles whose size ranges from 50–150 nm in diameter (so-called exosomes) up to 1 mm (microvesicles, MVs). EVs can be isolated from different body fluids such as serum and plasma, saliva, urine, breast milk and cerebrospinal fluid. For this reason, the EV cargo, consisting of DNA, RNA (including non-coding RNA), lipids and proteins, can be considered potential liquid biopsy biomarkers in many diseases, particularly for cancer diagnosis, prognosis, and to define metastatic status and recurrences.
Moreover, the biologically active molecules present in the EVs can be transferred from a “donor cell” (secreting EVs) to a “recipient cell” where the EV cargo can modulate gene expression, hence regulating their physiological status. EVs can also regulate several oncogenic processes, including tumor initiation, progression and metastasis, inducing, for example, angiogenesis, recruitment of cancer-associated fibroblasts, and extracellular matrix remodeling. All these features make EVs very important cell-to-cell mediators.
This Special Issue of Cancers will present and discuss original articles and review manuscripts aimed at investigating EV cargo identification and accurate functional characterization; the role of EVs and their cargos as mediators of cell communication at the microenvironment level; mechanisms of cargo recruitment, sorting and transfer to recipient cells; EV structural analyses; and the role of EV cargo as potential biomarkers for disease diagnosis and prognosis.
Dr. Lucia Casadei
Dr. Federica Calore
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- extracellular vesicles
- exosomes
- microvesicles
- microenvironment
- cell-to-cell communication
- DNA
- RNA
- microRNAs
- cancer
- lncRNAs
- recipient cell
- cargos
- biomarkers
- liquid biopsy