Early Gastric Cancer

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (10 March 2023) | Viewed by 12152

Special Issue Editors

1. Department of Surgery, Amsterdam UMC location University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
2. Cancer Treatment and Quality of Life, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands
Interests: fluorescence guided surgery; artificial intelligence in surgery; robot-assisted surgery
Special Issues, Collections and Topics in MDPI journals
Keio University Hospital, Tokyo 1608582, Japan.
Interests: gastric cancer; esophageal cancer; gastro-esophageal junction cancer; lymph node metastases; lymphadenectomy; sentinel node navigation surgery; gastric-preserving surgery

Special Issue Information

In this Special Issue of Cancers, entitled “Early Gastric Cancer”, current knowledge and aspects of early gastric cancer will be addressed. This Special Issue will focus on function-preserving techniques, lymph node dissection, and new minimally invasive techniques. Regarding function preservation, different aspects of several function-preserving gastrectomies will be discussed, such as laparoscopic proximal gastrectomy with double tract reconstruction. In addition, new oncologic techniques for lymphadenectomy, such as sentinel node navigation surgery in combination with minimally invasive surgery, and the evidence for a D2 versus a D3 dissection for advanced gastric cancer will be evaluated. Furthermore, new minimally invasive, hybrid, and endoscopic techniques, such as combining surgery and endoscopy in non-exposed endoscopic wall-inversion surgery, will be discussed.

Dr. Suzanne S. Gisbertz
Prof. Dr. Yuko Kitagawa
Guest Editors

Manuscript Submission Information

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Keywords

  • early gastric cancer
  • function-preserving gastrectomy
  • sentinel node navigation surgery
  • minimally invasive gastrectomy
  • hybrid techniques (endoscopy/surgery).

Published Papers (3 papers)

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Research

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12 pages, 7558 KiB  
Article
Securing Resection Margin Using Indocyanine Green Diffusion Range on Gastric Wall during NIR Fluorescence-Guided Surgery in Early Gastric Cancer Patients
by Minah Cho, Ki-Yoon Kim, Sung Hyun Park, Yoo Min Kim, Hyoung-Il Kim and Woo Jin Hyung
Cancers 2022, 14(21), 5223; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14215223 - 25 Oct 2022
Cited by 5 | Viewed by 1220
Abstract
Near-infrared (NIR) fluorescence lymphography-guided minimally invasive gastrectomy using indocyanine green (ICG) is employed to visualize draining lymphatic vessels and lymph nodes. Endoscopically injected ICG spreads along the gastric wall and emits fluorescence from the serosal surface of the stomach. We aimed to assess [...] Read more.
Near-infrared (NIR) fluorescence lymphography-guided minimally invasive gastrectomy using indocyanine green (ICG) is employed to visualize draining lymphatic vessels and lymph nodes. Endoscopically injected ICG spreads along the gastric wall and emits fluorescence from the serosal surface of the stomach. We aimed to assess the efficacy of ICG diffusion in securing the resection margin. We retrospectively analyzed 503 patients with early gastric cancer located in the body of the stomach who underwent fluorescence lymphography-guided gastrectomy from 2018 to 2021. One day before surgery, ICG was endoscopically injected into four points of the submucosal layer peritumorally. We measured the extent of resection and the resection line based on the ICG diffusion area from the specimen using NIR imaging. The mean area of the ICG diffusion was 82.7 × 75.3 and 86.7 × 80.2 mm2 on the mucosal and serosal sides, respectively. After subtotal gastrectomy, the length of the proximal resection margin was 38.1 ± 20.1, 33.4 ± 22.2, and 28.7 ± 17.2 mm in gastroduodenostomy, loop gastrojejunostomy, and Roux-en-Y gastrojejunostomy, respectively. The ICG diffusion area along the gastric wall secured a resection margin of >28 mm. The ICG diffusion range can be used as a simple and easy method for determining the resection margin during gastrectomy using NIR imaging. Full article
(This article belongs to the Special Issue Early Gastric Cancer)
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Review

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11 pages, 1694 KiB  
Review
Endoscopic Classifications of Early Gastric Cancer: A Literature Review
by Mary Raina Angeli Fujiyoshi, Haruhiro Inoue, Yusuke Fujiyoshi, Yohei Nishikawa, Akiko Toshimori, Yuto Shimamura, Mayo Tanabe, Haruo Ikeda and Manabu Onimaru
Cancers 2022, 14(1), 100; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14010100 - 26 Dec 2021
Cited by 17 | Viewed by 7222
Abstract
Endoscopic technologies have been continuously advancing throughout the years to facilitate improvement in the detection and diagnosis of gastric lesions. With the development of different endoscopic diagnostic modalities for EGC, several classifications have been advocated for the evaluation of gastric lesions, aiming for [...] Read more.
Endoscopic technologies have been continuously advancing throughout the years to facilitate improvement in the detection and diagnosis of gastric lesions. With the development of different endoscopic diagnostic modalities for EGC, several classifications have been advocated for the evaluation of gastric lesions, aiming for an early detection and diagnosis. Sufficient knowledge on the appearance of EGC on white light endoscopy is fundamental for early detection and management. On the other hand, those superficial EGC with subtle morphological changes that are challenging to be detected with white light endoscopy may now be clearly defined by means of image-enhanced endoscopy (IEE). By combining magnifying endoscopy and IEE, irregularities in the surface structures can be evaluated and highlighted, leading to improvements in EGC diagnostic accuracy. The main scope of this review article is to offer a closer look at the different classifications of EGC based on several endoscopic diagnostic modalities, as well as to introduce readers to newer and novel classifications, specifically developed for the stomach, for the assessment and diagnosis of gastric lesions. Full article
(This article belongs to the Special Issue Early Gastric Cancer)
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13 pages, 783 KiB  
Review
Function-Preserving Gastrectomy for Early Gastric Cancer
by Yoshihiro Hiramatsu, Hirotoshi Kikuchi and Hiroya Takeuchi
Cancers 2021, 13(24), 6223; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers13246223 - 10 Dec 2021
Cited by 8 | Viewed by 2791
Abstract
Recently, minimally invasive (endoscopic or laparoscopic) treatment for early gastric cancer (EGC) has been widely accepted. However, a standard gastrectomy with radical lymphadenectomy is generally performed in patients with EGC who have no indications for endoscopic resection, and postgastrectomy dysfunction is one of [...] Read more.
Recently, minimally invasive (endoscopic or laparoscopic) treatment for early gastric cancer (EGC) has been widely accepted. However, a standard gastrectomy with radical lymphadenectomy is generally performed in patients with EGC who have no indications for endoscopic resection, and postgastrectomy dysfunction is one of the problems of standard gastrectomy. Function-preserving gastrectomy, such as proximal gastrectomy and pylorus-preserving gastrectomy, can be considered when attempting to preserve the patient’s quality of life (QOL) postoperatively. In addition, sentinel node navigation surgery for EGC has been applied in clinical practice in several prospective studies on function-preserving personalized minimized gastrectomy. In the near future, the sentinel lymph node concept is expected to form the basis for establishing an ideal, personalized, minimally invasive function-preserving treatment for patients with EGC, which will improve their postoperative QOL without compromising their long-term survival. In this review article, we summarize the current status, surgical techniques, and postoperative outcomes of function-preserving gastrectomy for EGC. Full article
(This article belongs to the Special Issue Early Gastric Cancer)
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