Special Issue "Genomic Instability in Tumor Evolution and Therapy Response"
Deadline for manuscript submissions: 1 May 2022.
Interests: RB/E2F pathway; cell cycle; transcriptional regulation; genomic stability; cell proliferation
Special Issues, Collections and Topics in MDPI journals
Interests: Cell cycle; Transcriptional regulation; Genomic stability; Replication stress
The integrity of the human genome is closely managed by an array of cell surveillance mechanisms, and its maintenance is essential for organism survival. To guarantee genomic integrity, cells have developed a highly sophisticated molecular network that ensures faithful DNA replication, repair of all types of DNA damage and accurate chromosome segregation in mitosis.
Genomic instability arises from perturbations involving failure to repair DNA damage, exogenous or endogenous genotoxic stress that overwhelms high-fidelity DNA replication and repair, oncogene-induced replication stress, chromothripsis, telomere dysfunction or defective mitosis, and it is presently considered a major driver of cancer development and progression. Moreover, persistent genome instability in tumors has been associated with their increased aggressive behavior and resistance to cancer therapies; consequently, it has prognostic and therapeutic significance.
This Special Issue is focused on studies that highlight recent advances in our understanding of genomic stability maintenance, from the drivers of instability to the cellular responses, as well as progress that is being made based on its exploitation as a vulnerability for cancer treatment. We cordially invite researchers working actively in these fields to submit their original research or review manuscripts to this Special Issue on genomic instability.
Dr. Ana María Zubiaga
Dr. Jone Mitxelena
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- genomic instability
- DNA damage response
- replication stress
- oncogenic stress
- transcription–replication conflicts
- common fragile sites
- telomere dysfunction
- chromosome fragility
- immune response to genome instability
- precision therapy