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Cancers
Special Issues
Lifestyles and Hepatocellular Carcinoma
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Lifestyles and Hepatocellular Carcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 7731

Special Issue Editor

Prof. Dr. Jean-François Dufour

E-Mail Website
Guest Editor
University Clinic of Visceral Surgery and Medicine, Inselspital Bern, Switzerland
Interests: NASH HCC physical activity

Special Issue Information

Dear Colleagues,

The liver is an organ especially sensitive to lifestyles. The way people live affects their risk to develop a liver disease and particularly a liver cancer. In the last years a large amount of evidence has been supported this regarding diet, physical activity, coffee, smoking. Some drugs may mimicks these benefits and they are of particular interest in patients with NASH since they are metabolic drugs or used to prevent cardiovascular events. This special issue will review in depth the current literature and identify areas where more data are urgently needed.

Prof. Dr. Jean-François Dufour
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver cancer
  • hepatocellular carcinoma
  • NASH
  • MAFLD
  • diabetes
  • obesity
  • physical activity
  • diet
  • coffee
  • fasting
  • systemic therapy
  • curative therapy
  • aspirin
  • statin
  • metformin

Published Papers (3 papers)

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Review

17 pages, 776 KiB  
Review
Recreational Drugs and the Risk of Hepatocellular Carcinoma
by José M. Pinazo-Bandera, Miren García-Cortés, Antonio Segovia-Zafra, María Isabel Lucena and Raúl J. Andrade
Cancers 2022, 14(21), 5395; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14215395 - 02 Nov 2022
Cited by 3 | Viewed by 1888
Abstract
Recreational or aesthetic drug use is a distinctive behavior of humans, principally attested in the last century. It is known that recreational and illegal drugs are major contributors to the universal morbidity rate worldwide. Many of these substances have a well-established hepatotoxic potential, [...] Read more.
Recreational or aesthetic drug use is a distinctive behavior of humans, principally attested in the last century. It is known that recreational and illegal drugs are major contributors to the universal morbidity rate worldwide. Many of these substances have a well-established hepatotoxic potential, causing acute or chronic liver injury, liver fibrosis and cirrhosis, but their implications for hepatocellular carcinoma or other varieties of liver tumors are little known. In this article, we perform an extensive literature review, aiming to provide updated information about recreational drug use and the risk of developing liver tumors. Khat use and pyrrolizidine alkaloid consumption (present in some natural plants) have been linked to liver cirrhosis. Kava intake is associated with different liver tumors in animal models but not in humans. Cannabis’ potential to accelerate liver fibrosis in chronic hepatitis is controversial according to the existing data. Cigarette smoking is an important contributor to hepatocellular carcinoma, and anabolic androgen steroids are well-defined causes of a variety of liver cancers and other hepatic tumors. Long-term follow-up studies of subjects who have developed injuries in association with the use of recreational drugs are warranted so as to better define the risk of developing hepatocellular carcinoma in association with these substances and, thus, to implement health care policies to combat this preventable cause of cancer. Full article
(This article belongs to the Special Issue Lifestyles and Hepatocellular Carcinoma)
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Graphical abstract

15 pages, 609 KiB  
Review
What Is the Role of Body Composition Assessment in HCC Management?
by Pompilia Radu, Maryam Ebadi, Aldo J. Montano-Loza and Jean Francois Dufour
Cancers 2022, 14(21), 5290; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14215290 - 27 Oct 2022
Cited by 3 | Viewed by 1460
Abstract
In the last decade, body composition (BC) assessment has emerged as an innovative tool that can offer valuable data concerning nutritional status in addition to the information provided by the classical parameters (i.e., body mass index, albumin). Furthermore, published data have revealed that [...] Read more.
In the last decade, body composition (BC) assessment has emerged as an innovative tool that can offer valuable data concerning nutritional status in addition to the information provided by the classical parameters (i.e., body mass index, albumin). Furthermore, published data have revealed that different types of body composition are associated with different outcomes. For example, abnormalities of skeletal muscle, a common finding in cirrhotic and oncologic patients, are associated with poor outcome (i.e., high morbidity and high mortality). The disposition (visceral/subcutaneous adipose tissue) and radiodensity of adipose tissue proved to also be determinant factors for HCC outcome. Despite all the advantages, BC assessment is not part of the standard pre-therapeutic workup. The main reasons are the high heterogeneity of data, the paucity of prospective studies, the lack of a standard assessment method, and the interpopulation variation of BC. This paper aims to review the available evidence regarding the role of BC as a prognostic tool in the HCC population undergoing various therapies. Full article
(This article belongs to the Special Issue Lifestyles and Hepatocellular Carcinoma)
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Graphical abstract

18 pages, 692 KiB  
Review
Is Fasting Good When One Is at Risk of Liver Cancer?
by Iulia Minciuna, Laurens A. van Kleef, Horia Stefanescu and Bogdan Procopet
Cancers 2022, 14(20), 5084; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers14205084 - 17 Oct 2022
Cited by 4 | Viewed by 3870
Abstract
Hepatocellular carcinoma (HCC), one of the leading causes of cancer-related deaths worldwide, is a multistep process that usually develops in the background of cirrhosis, but also in a non-cirrhotic state in patients with non-alcoholic fatty liver disease (NAFLD) or viral hepatis. Emerging evidence [...] Read more.
Hepatocellular carcinoma (HCC), one of the leading causes of cancer-related deaths worldwide, is a multistep process that usually develops in the background of cirrhosis, but also in a non-cirrhotic state in patients with non-alcoholic fatty liver disease (NAFLD) or viral hepatis. Emerging evidence suggests that intermittent fasting can reduce the risk of cancer development and could improve response and tolerance to treatment through the metabolic and hormonal adaptations induced by the low energy availability that finally impairs cancer cells’ adaptability, survival and growth. The current review will outline the beneficial effects of fasting in NAFLD/NASH patients and the possible mechanisms that can prevent HCC development, including circadian clock re-synchronization, with a special focus on the possibility of applying this dietary intervention to cirrhotic patients. Full article
(This article belongs to the Special Issue Lifestyles and Hepatocellular Carcinoma)
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