Dear Colleagues, 

Breast cancer is the leading malignancy worldwide with 2.26 million new cases diagnosed in 2020 and an increasing incidence. Approximately 70–80% of tumors are hormone-receptor positive and therefore are considered for endocrine therapy. Treatment modalities depend on patients’ menopausal status, tumor stage, performance status, and tumor markers. More than 30% of patients in the adjuvant and even more in advanced stages suffer from disease progress due to intrinsic or acquired resistance against endocrine therapy. To overcome treatment failures, including drug discontinuation due to drug-induced toxicity, better prognostic markers—but also new treatment opportunities—are needed.

This Special Issue will focus on basic, translational, and clinical studies aiming to improve endocrine therapy by the identification of new and better predictors for personalized treatment decisions and therapeutic approaches, including the selection of multimodal targets, the use of bioinformatic prediction tools, and both mechanistic and clinical investigations to overcome endocrine drug failure in breast cancer.

Dr. Thomas Mürdter
Dr. Werner Schroth
Guest Editors

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• hormone
• therapy
• breast cancer
• estrogens
• resistance
• combinational therapy
• anti-estrogens, kinase inhibitors
• checkpoint inhibitors
• chemotherapy
• in vitro models
• clinical trials