Dear Colleagues,

Adrenal tumors are common and are often incidentally discovered during imaging (adrenal incidentalomas). Most of the adrenal tumors are indolent hormonally inactive tumors of adrenocortical origin, but hormonally active adrenocortical tumors (primary aldosteronism, Cushing-syndrome), adrenomedullary pheochromocytomas, and adrenocortical cancer have significant morbidity and mortality.

Pheochromocytomas are rare, but exceptional germ-line genetic mutations are found in 30–40% of cases, and somatic mutations are also important. Several novel genes and pathomechanisms have been established in recent years in their pathogenesis.

Major advances have taken also place in our understanding of the genetics of primary aldosteronism and adrenal Cushing’s syndrome. Rare monogenic tumor syndromes (e.g., Li–Fraumeni and Beckwith–Wiedemann syndromes) are known to predispose patients to adrenocortical cancer, and understanding their pathogenesis is important to decipher the pathogenesis of their sporadic counterparts.

Recent studies using high-throughput bioinformatics approaches have contributed to significant progress in genomics and epigenomics of adrenal tumors that involve both the analysis of transcriptome, methylome, miRnome and other non-coding RNA. Novel biomarkers of adrenal malignancy and tumor classification can be developed based on these observations.

The Special Issue aims to cover several aspects of both adrenocortical tumors and pheochromocytomas involving advances in both genetics and epi/genomics.

Prof. Dr. Peter Igaz
Guest Editor

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• adrenal tumor
• adrenal incidentaloma
• primary aldosteronism
• adrenal Cushing’s syndrome
• adrenocortical cancer
• pheochromocytoma
• malignant pheochromocytoma
• hereditary
• multiple endocrine neoplasia syndromes
• susceptibility gene
• pseudohypoxia
• transcriptomics
• methylome
• microRNA
• miRnome
• non-coding RNA
• genetics
• epigenetics
• genomics
• epigenomics
• biomarker
• tumor classification