Circulating Biomarkers in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".
Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 24352
Special Issue Editor
Special Issue Information
Dear Colleagues,
Tissue biopsy is the standard procedure for cancer diagnosis and also provides material for biomarker testing. However, this approach has some limitations due to tumor heterogeneity and neoplasm evolution, and in some cases, the lack of availability or insufficient amount of tumor tissue.
The analysis of circulating tumor DNA (ctDNA) is a promising diagnostic approach to obtain information about the biology of many cancer types. First, ctDNA genotyping has been proven to be a valid approach for non-invasive biomarker testing, especially in cancer patients in whom biopsies are not possible to obtain. In addition, many studies agree that ctDNA quantification significantly correlates with tumor load, and therefore, ctDNA quantification can be used for cancer staging and to monitor tumor response to treatment. ctDNA analysis can also be useful for the identification of resistance mutations. Finally, improvements in assay sensitivity are facilitating the development of liquid biopsy-based tests for the detection of ctDNA at very low allele frequencies (AFs), which can be used for the measurement of minimal residual disease and ultimately for the development of screening strategies.
This Special Issue will highlight the role of circulating biomarkers in cancer as a revolutionary tool for cancer management, covering both basic and clinical aspects, including detection methods and potential applications in tumor diagnosis, treatment, and prognosis in different types of neoplasms.
Dr. Atocha Romero
Guest Editor
Manuscript Submission Information
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Keywords
- liquid biopsy
- targeted therapy
- circulating DNA
- prognosis
- tumoral response
- exosomes
- miRNAs
- tumoral detection