Dear Colleagues,

It is now widely admitted that cancer cells strongly interact with their surrounding cells, and extracellular vesicles (EV) emerge as new players in the regulation of the tumor microenvironment. EVs have been historically classified on the basis or their size. Endosome-origin exosomes are small (30-150 nm in diameter) extracellular nanovesicles containing miRNAs, mRNAs, DNAs, proteins, lipids among others. Microvesicles (MVs) (100-1000 nm in diameter) are generated directly from the plasma membrane by budding. Some studies report a third class of EVs, the apoptotic bodies (ABs), which are large EVs (often >1000 nm in diameter). ABs are implicated in cell signaling but they are not always considered as EV as they are only secreted during a very precise context, programmed cell death. This Special Issue will highlight the implication of EVs in the pathophysiology of urogenital cancers (kidney, prostate, bladder, testicle, head & neck, ovarian cancer). Notably, the role of EVs and their components in tumorigenesis of primary tumor cells and in the onset and dissemination of metastasis will be described. Other functions of EVs, for example as diagnostic tools or predictors of disease outcome could be explained. Finally, the description of the later literature and novel findings will be much appreciated.

Dr. Leyre Brizuela
Dr. Mebarek Saida
Guest Editors

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• Extracellular Vesicles
• Exosomes
• Microvesicles
• Lipid Signaling
• Kidney
• Prostate
• Bone Metastasis