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Special Issue Editors

Prof. Dr. Janusz Jurczak

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Guest Editor

Institute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland
Interests: organic chemistry; supramolecular chemistry; asymmetric catalysis; supramolecular processes; high-pressure methods

Dr. Piotr Kwiatkowski

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Guest Editor

Faculty of Chemistry, University of Warsaw, Warsaw, Poland
Interests: organocatalysis; organocatalytic; asymmetric synthesis; organic synthesis; organic chemistry

Dr. Patryk Niedbała

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Guest Editor

Institute of Organic Chemistry of the Polish Academy of Sciences, Warsaw, Poland
Interests: chiral catalysts; phase-transfer reactions; organic chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to present this Special Issue of Catalysts dedicated to Nobel Laureates of 2021—Benjamin List and David MacMillan. The field of organocatalysis is currently one of the most important branches of modern organic synthesis. We hope that many colleagues will be highly interested in collaborating and present their research in our Special Issue.

Prof. Dr. Janusz Jurczak
Dr. Piotr Kwiatkowski
Dr. Patryk Niedbała
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

synthesis of organocatalysts
studies on structure of organocatalysts
application of organocatalysis to synthesis
organocatalytic processes and reactions
mechanism of organocatalytic reactions
asymmetric synthesis
synthesis of natural products
application of nonconventional methods for organocatalytic reactions and processes
application of high-pressure
application of sonochemistry

Published Papers (1 paper)

Review

15 pages, 4970 KiB

Open AccessReview

Organocatalytic Synthesis of α-Aminonitriles: A Review

by Bakhtar Ullah, Navneet Kumar Gupta, Quanli Ke, Naseeb Ullah, Xingke Cai and Dongqing Liu

Catalysts 2022, 12(10), 1149; https://0-doi-org.brum.beds.ac.uk/10.3390/catal12101149 - 01 Oct 2022

Cited by 6 | Viewed by 1867

Abstract

α-Aminonitriles, which have anticancer, antibacterial, antiviral, and antifungal properties, have played an important role in pharmacology. Furthermore, they can also be used to synthesize natural and unnatural amino acids. The main bottleneck in the commercialization of these products is their large-scale production with controlled chirality. A variety of methods have been used to synthesize α-aminonitriles. Among other reported methods for preparing α-aminonitriles, the Strecker reaction is considered appropriate. Recent developments, however, have enabled the α-cyanation of tertiary and secondary amines by functionalizing the carbon–hydrogen (C–H) bond as an attractive alternative procedure for the preparation of α-aminonitriles in the presence of an oxidant and a cyanide source. In most cases, these reactions are catalyzed by transition metal catalysts, such as Fe, Cu, Rh, V, Au, Ru, Mo, Pt, Re, and Co, or by photocatalysts. As an alternative, organocatalysts can also be used to produce aminonitriles. Although there have been numerous reviews on the preparation of α-aminonitriles, no such reviews have been published specifically on the organocatalyzed synthesis of α-aminonitriles. Organocatalysis plays a significant role in synthesizing α-aminonitriles via Strecker-type reactions and cross dehydrogenative coupling reactions (CDC). In this mini review, we discuss the organocatalyzed synthesis of these molecules. A review of new organocatalysts for the synthesis of aminonitriles is expected to provide insight into the development of new industrial catalysts. Full article

(This article belongs to the Special Issue Advances in Organocatalysis Applied for Organic Synthesis: Celebrating the Nobel Prize in 2021)

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