Recent Advances in Asymmetric Catalysis

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2663

Special Issue Editor


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Guest Editor
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm, Sweden
Interests: asymmetric catalysis; enantoselective multicomponent borylative coupling; hypervalent iodine(III) chemistry; biomimetic oxidation; C-H functionalization

Special Issue Information

Dear Colleagues,

Asymmetric catalysis has emerged as a powerful tool in recent years. Numerous organo-catalyzed and metal-catalyzed enantioselective methods have been found to be promising approaches for generating high-value stereodefined compounds. Enantioenriched molecules attained via asymmetric transformation possess various functional groups, such as amino, cyano, azide, silyl, and boronate groups, which are used in the synthesis of many natural products and biologically and medicinally important molecules. Asymmetric boraylation, silylation, cyanation, and azidation are particularly attractive because they enable the synthesis of further target molecules. Asymmetric catalysis is remarkable for its stereodefined chemical synthesis, which has potential applications in medicinal chemistry.

In modern organic synthesis, asymmetric catalysis has emerged as a particularly effective method for generating enantiomerically enriched molecules. Numerous transition metal-catalyzed enantioenriched chemical synthesis methods have emerged as promising approaches for generating high-value stereodefined compounds over the past few decades. Enantioenriched molecules via asymmetric transformation contain various functionalities such as amino, cyano, and boronate groups, which are used in the synthesis of many natural products, and biologically and medicinally important molecules. Asymmetric boraylation, silylation, cyanation, and azidation are particularly attractive because they enable for the synthesis of further target molecules.

Short reviews that reflect the state of research in asymmetric catalysis on the following topics are welcome for submission to this Special Issue on Recent Advances in Asymmetric Catalysis. Asymmetric borylation of alkenes, allenes, dienes and enynes, asymmetric silylation, asymmetric alkynylation, asymmetric cyanation, asymmetric trifluoromethylation, nickel catalyzed asymmetric multicomponent reaction, and iron-catalyzed asymmetric hydrosilylation are all topics that we are interested in publishing research regarding.

Dr. Srimanta Manna
Guest Editor

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Keywords

  • asymmetric borylation
  • asymmetric silylation
  • asymmetric alkynylation
  • asymmetric cyanation
  • asymmetric trifluoromethylation

Published Papers (1 paper)

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Review

18 pages, 3287 KiB  
Review
Copper-Catalyzed Diastereo- and Enantioselective Borylative Cyclization
by Srimanta Manna
Catalysts 2022, 12(7), 734; https://0-doi-org.brum.beds.ac.uk/10.3390/catal12070734 - 02 Jul 2022
Cited by 4 | Viewed by 2136
Abstract
Copper-catalyzed enantioselective borylative cyclization with various electrophiles via difunctionalization of unsaturated hydrocarbons is a powerful tool for the generation of interesting boron-containing carbocycles and heterocycles processes involving a chiral organocopper intermediate. Alkenes, allenes, and alkynes are versatile and easily accessible substrates that can [...] Read more.
Copper-catalyzed enantioselective borylative cyclization with various electrophiles via difunctionalization of unsaturated hydrocarbons is a powerful tool for the generation of interesting boron-containing carbocycles and heterocycles processes involving a chiral organocopper intermediate. Alkenes, allenes, and alkynes are versatile and easily accessible substrates that can be subjected to a wide range of reactions to produce densely functionalized, enantioenriched products. In this chapter, I discuss copper-catalyzed alkenes, allenes, and alkynes borofunctionalization and enantioselective cyclization via chiral organocopper intermediate. Copper-catalyzed enantioselective borylative cyclization and regiodivergent functionalization of alkenes, allenes, and alkynes, as well as the current mechanistic understanding of such processes, are given special attention in this review. Full article
(This article belongs to the Special Issue Recent Advances in Asymmetric Catalysis)
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