Lipid Membranes and Lipid-Like Molecules Catalyze Protein Aggregation
A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 549
Special Issue Editors
Interests: protein structure and function; protein–membrane interaction; neurodegeneration; protein misfolding; electron paramagnetic resonance
Interests: amyloid toxicity; fibril structure; protein–membrane interaction; non-fibrillar amyloid intermediates; modeling and simulation of amyloids
Interests: protein misfolding and aggregation; protein–membrane interaction; membrane-mediated protein aggregation; phase transition in proteins; amyloid misfolding intermediates
Special Issue Information
Dear Colleagues,
Protein misfolding and aggregation are central to cellular toxicity observed in many diseases. Among these are many age-related diseases such as Alzheimer’s disease, Parkinson’s disease, age-related macular degeneration, and Huntington’s disease. Generally, specific proteins have been implicated in such diseases and have been shown to undergo monomer to fibril transition through oligomeric forms. Many studies underscore the importance of identifying and understanding the mechanism(s) that promote(s) this transition. Among several factors promoting misfolding and aggregation of such proteins, lipid membranes and lipid-like molecules are of prime importance due to their abundance in the cellular environment and unique physicochemical properties. Notably, lipid and protein co-aggregates have been commonly observed in the plaques from autopsy samples of many age-related diseases.
This Special Issue is focused on studies investigating the effect of lipid membranes and lipid-like molecules on misfolding and aggregation of proteins and peptides implicated in several diseases of neuronal and non-neuronal origin. We invite original research articles, reviews, mini-reviews, and short articles covering molecular, structural, mechanistic, and cellular aspects of membrane-mediated protein misfolding and toxicity.
Dr. Jobin Varkey
Dr. Anoop Rawat
Dr. Nitin Kumar Pandey
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein misfolding
- lipid membrane
- amyloid toxicity
- amyloid structure
- protein aggregation
- protein–lipid interaction
