New Frontiers in Catalytic Asymmetric Functionalization of Alkenes
A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 294
Special Issue Editor
Special Issue Information
Dear Colleagues,
Alkenes are important and valuable building blocks for organic synthesis because of their wide availability and diverse reactivity. Fundamentally, the reactivity of alkene pi-bonds allows incorporation of various atoms and groups by either hydrofunctionalization or difunctionalization through different manifolds, including direct electrophilic addition, radical addition, and transition-metal activation. Owing to these distinct pathways, the past two decades have witnessed the rapid growth of alkene functionalization, which has now become one of the most versatile platforms in organic synthesis.
In particular, catalytic enantioselective functionalization of alkenes has enabled access to a wide array of chiral compounds containing diverse functional groups. Asymmetric epoxidation and dihydroxylation are classical examples in this topic. Recent progress in asymmetric hydrofunctionalization has significantly broadened the scope of unactivated alkenes while achieving excellent enantioselectivity. Transition-metal-catalyzed enantioselective difunctionalization of alkenes is another exciting direction that has seen a burgeoning of new methods in recent years, particularly with nickel, copper, and palladium. In addition, the ability of transition metal to intercept radical intermediates in a stereoselective manner offers new opportunities in this area by combining single-electron redox chemistry. Finally, advances in halofunctionalization, chalcofunctionalization and aminofunctionalization are driven by designing chiral main-group catalysts that explore new scaffolds and non-covalent interactions.
This Special Issue aims to highlight some of the most recent and significant developments in the catalytic asymmetric functionalization of alkenes. Submissions are welcome in the form of original research papers or short reviews.
Dr. Yumeng Xi
Guest Editor
Manuscript Submission Information
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Keywords
- alkene functionalization
- alkyne functionalization
- asymmetric catalysis
- transition metal
- organocatalysis
- regioselectivity