Mitochondria in Acute and Chronic Neurodegeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 736
Special Issue Editors
Interests: mitochondrial dysfunction in nervous system; stroke; neuronal bioenergetics; cell death signaling; glucose metabolism; neuronal calcium and redox homeostasis
Interests: mitochondrial dysfunction; ischemia/reperfusion injury; mitochondrial dynamics; mitochondrial quality control
Special Issue Information
Dear colleagues,
Mitochondria are important organelles for the maintenance of cellular bioenergetics, calcium homeostasis, and redox balance. Neurons are highly dependent on the mitochondrial function to meet their demanding bioenergetic needs as well as calcium and oxidative homeostasis needs. Therefore, mitochondrial health is of vital importance for neuronal function and survival. Even minor alterations in mitochondrial function or mitochondrial turnover can cause deleterious effects on the survival and function of neurons. Mitochondrial dysfunction comprises a dominant pathological pathway in acute neuronal injury as well as in chronic neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis. Understanding how mitochondrial dysfunction results in different neurodegenerative diseases or how different neurodegenerative processes or neuronal injuries converge to mitochondrial dysfunction holds an important key for therapeutic intervention in acute and chronic neurodegeneration.
Dr. Shaida A. Andrabi
Dr. Thomas H. Sanderson
Guest Editors
Manuscript Submission Information
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Keywords
- Mitochondria
- Neurodegenerative diseases
- Redox homeostasis
- Calcium buffering
- Cell death
- Glycolysis
- Mitophagy
- Electron transport chain
- Mitochondrial biogenesis
- Mitochondrial DNA
- Synaptic mitochondria
- Ischemia/reperfusion injury
- Traumatic brain injury
