Mitochondrial Biology Regulation in Health and Diseases

Dear colleagues,

A mitochondrion is probably the most fascinating organelle contributing besides energy production in almost all aspects of cellular life. Regulation of cellular redox balance and thermogenesis, control of gene expression and metabolic pathways, and contribution to the various cell signaling pathways are just a few ways that mitochondria affect cell life. Hence, mitochondrial homeostasis is a key requirement for cell and organismal health. Dysregulations of mitochondrial dynamics, motility, communication with other organelles, mitogenesis, or mitophagy lead to severe diseases like cancer, neurodegenerative and cardiovascular diseases, diabetes, and inflammation. Numerous extra- and intramitochondrial signaling pathways provide essential transcriptional or post-translational control of mitochondrial function. Interestingly, mitochondria possess several of their own signaling pathways, i.e., separated from cytosolic, regulating post-translational mitochondrial protein modification, e.g., intra-mitochondrial cAMP/cGMP signaling, Sirt3.

This Special Issue aims to bring together a collection of original research and review articles highlighting all aspects of mitochondrial biology regulation, including, among others, OXPHOS activity, ROS formation, apoptosis, mitochondrial life cycle, dynamics, and communication with the nucleus and other organelles.

A special interest of the Issue is the presentation of new mechanisms leading to the disturbance of mitochondrial biology under stress conditions and in diseases.

The Special Issue welcomes high-quality studies applying cell and animal models. Clinical studies, if relevant, as well as computational modeling are also welcome.

Dr. Yury Ladilov
Dr. Patrice X. Petit
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cardiolipin
• mitochondrial biogenesis
• mitochondrial DNA
• mitochondrial dynamics
• mitochondrial gene expression
• mitochondrial signaling
• mitochondrial membrane transporters
• mitochondrial permeability transition
• mitochondrial sirtuins
• mitochondrial cAMP
• TCA
• aging