Organ Specificity in DNA Repair/DDR in Solid Cancers
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 429
Special Issue Editors
2. Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
3. First Faculty of Medicine, Charles University, Prague, Czech Republic
Interests: colorectal cancer; pancreatic cancer; DNA damage and repair; telomere length; chromosomal damage
2. Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
3. First Faculty of Medicine, Charles University, Prague, Czech Republic
Interests: DNA and chromosomal damage; DNA repair; colorectal cancer; pancreatic cancer; cancer risk; cancer prognosis; therapy prediction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
There is ample evidence for the essential involvement of DNA repair and DNA damage response (DDR) in the onset and progression of solid cancer malignancies. The literature indicates that every DDR process is functionally impaired to some extent in one or more cancer types. Among effector pathways of DDR, genomic alterations in DNA repair genes represent substantial changes underlying the genetics of many solid cancers (e.g., breast, ovarian, and colorectal cancer). This paradigm is particularly pronounced in familial cancers with known germline mutations in DNA-repair genes.
Regarding the role of DDR in ensuring genomic stability in cells within organisms and in preventing cancer, several questions need to be addressed. One of these may be the dynamics of DDR and DNA repair throughout the life-span of cells/organisms. Is aging indeed related to a decrease in DNA repair capacity, whereas the proliferative activity of cells is also diminished? Are there differences in DNA repair/DDR in individual organs/tissues, and if so, are these differences associated with cellular turnover? Does the kinetics of DNA repair/DDR affect the critical site of tumor onset?
The aim of this Special Issue is to address the pivotal role of DDR in essential biological processes, such as malignant transformation or degenerative diseases. Another goal is to survey currently existing data on solid cancer onset, prognosis, and treatment efficacy.
Dr. Ludmila Vodičková
Dr. Pavel Vodička
Guest Editors
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Keywords
- DNA repair
- DNA damage response
- organ specificity
- prevailing molecular damage
- chromosomal instability phenotype
