Vesicular Trafficking Meets Nuclear Transport
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (10 March 2022) | Viewed by 1196
Special Issue Editors
Interests: nucleo-cytoplasmic shuttling; protein–protein interactions; antiviral drug discovery; viral replication
Special Issues, Collections and Topics in MDPI journals
Interests: intracellular trafficking; extracellular vesicles bio-physical properties; clinical biochemistry; extracellular vesicles in diagnostics
Interests: extracellular vesicles; nucleo-cytoplasmic trafficking of endocytic proteins; protein moonlighting; clinical biochemistry; diagnostics; intracellular trafficking
Special Issue Information
Dear Colleagues,
Extracellular Vesicles (EVs) are nanosized structures known to mediate the transfer of biomaterials between cells. EV cargoes include molecules originating from a wide range of cellular districts, surprisingly including the cell nucleus. This implies that nuclear proteins and genomic DNA can be actively packaged and secreted in EVs. In parallel, the presence of EV-carried biomolecules in the nuclei of receiving cells clearly suggests that the EV cargo may reach the nucleus by unconventional routes, for example, involving interactions between the endosomal and nuclear compartments.
This Special Issue aims to be the first comprehensive systematic collection of studies on this aspect, accepting original research and review articles, including but not limited to the following topics:
- Nucleocytoplasmic trafficking of EV-derived/enclosed material;
- EV loading with nuclear components;
- The nuclear envelope and the endosomal compartment as key players for vesicular nuclear trafficking;
- Nucleocytoplasmic shuttling endocytic adaptor proteins and protein moonlighting.
Dr. Gualtiero Alvisi
Dr. Lucia Paolini
Dr. Annalisa Radeghieri
Guest Editors
Manuscript Submission Information
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Keywords
- extracellular vesicles
- nucleo-cytoplasmic shuttling
- protein moonlighting
- endocytic proteins
- exosomes
