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Chemistry
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Recent Advances in Antimicrobial Materials
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Recent Advances in Antimicrobial Materials

A special issue of Chemistry (ISSN 2624-8549). This special issue belongs to the section "Chemistry of Materials".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 11006

Special Issue Editor

Prof. Dr. Simona Concilio

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, SA 84084 Fisciano, Italy
Interests: chemical synthesis; biomaterials; fluorescent probes; drug design
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial therapy is an effective way to treat various diseases and a key component of modern medical practice. Infections caused by disease-causing microorganisms are a big problem for many of us, particularly in the areas of medical devices, hospital surfaces, surgical equipment, and healthcare products, packaging, and storage of food.

Infections are usually controlled with antimicrobial agents; however, some bacteria have become resistant to common antibiotics after their genes have mutated, making them difficult to remove. As a result, the increased resistance of microorganisms to the current use of antimicrobial agents has led to evaluating other agents that may have an antimicrobial effect.

This Special Issue covers the latest developments and applications of antibacterial biomaterials, including simulation, mechanistic understanding, and uses of antimicrobial compounds and materials. It also intends to inspect the role of innovative approaches and provide an overview of cutting-edge research on treatments, properties, and technologies in the development of antimicrobial applications.

We invite scholars to contribute with original research articles and reviews on several pertinent topics, including but not limited to:

-  Synthesis of new antimicrobial molecules and nanoparticles;

-  Antimicrobial peptides;

-  Antimicrobial surfaces and coatings;

-  Models of activity, selectivity, and toxicity of antimicrobial agents;

-  Antimicrobial polymers;

-  Application for biomedical devices and food packaging;

-  Computational and bioinformatics approach to the design of novel antimicrobial agents.

You may choose our Joint Special Issue in Molecules.

Prof. Dr. Simona Concilio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemistry is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Related Special Issue

Published Papers (5 papers)

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Research

16 pages, 4040 KiB  
Article
Biogenic Silver and Copper Nanoparticles: Potential Antifungal Agents in Rice and Wheat Crops
by Paula Sanguiñedo, Ricardo Faccio, Eduardo Abreo and Silvana Alborés
Chemistry 2023, 5(4), 2104-2119; https://0-doi-org.brum.beds.ac.uk/10.3390/chemistry5040143 - 06 Oct 2023
Viewed by 911
Abstract
Metal nanoparticles are widely studied due to their various applications, such as their potential use in the control of phytopathogens and the promotion of plant growth, with a significant impact on agriculture. Various microbial metabolites are used to reduce and stabilize metals and [...] Read more.
Metal nanoparticles are widely studied due to their various applications, such as their potential use in the control of phytopathogens and the promotion of plant growth, with a significant impact on agriculture. Various microbial metabolites are used to reduce and stabilize metals and metal oxides to the nanoscale. In the present work, the biological synthesis of silver and copper oxide nanoparticles using Trichoderma harzianum TA2 is reported. The nanoparticles were purified and characterized with complementary methodologies to obtain information on the size, distribution, morphology, surface charge, and functional groups of the nanoparticles. The in vitro antifungal activity of the nanoparticles against pathogens of rice and wheat, as well as their effect on seed germination, were evaluated. In general, the nanoparticles showed a spherical shape, an average size of 17–26 nm, and low polydispersity. Furthermore, they showed antifungal activity at low concentrations against Sclerotium oryzae (0.140 ηM), Rhizoctonia oryzae-sativae (0.140 ηM), Fusarium graminearum (0.034 ηM), and Pyricularia oryzae (0.034 ηM). The germination of seeds treated with nanoparticles was not negatively affected. This is the first report of biogenic silver and copper oxide nanoparticles from a single strain of T.harzianum with antifungal activity against four phytopathogens of interest in Uruguay. Furthermore, the synthesis of the biogenic nanoparticles was faster and more efficient than previous reports using other fungi. In conclusion, this work reveals that biogenic metallic nanoparticles from T. harzianum TA2 can be considered as candidates for the control of phytopathogens affecting important crops. Full article
(This article belongs to the Special Issue Recent Advances in Antimicrobial Materials)
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16 pages, 1824 KiB  
Article
The Antimicrobial and Mosquitocidal Activity of Green Magnesium Oxide Nanoparticles Synthesized by an Aqueous Peel Extract of Punica granatum
by Amr Fouda, Khalid S. Alshallash, Mohammed I. Alghonaim, Ahmed M. Eid, Ahmed M. Alemam, Mohamed A. Awad and Mohammed F. Hamza
Chemistry 2023, 5(3), 2009-2024; https://0-doi-org.brum.beds.ac.uk/10.3390/chemistry5030136 - 12 Sep 2023
Cited by 2 | Viewed by 1392
Abstract
An aqueous extract of Punica granatum peel was used as a biocatalyst for magnesium oxide nanoparticle (MgO-NP) synthesis, which was characterized via UV-Vis spectroscopy, TEM, EDX, FT-IR, XRD, DLS, and zeta potential. Data showed the efficacy of the plant aqueous extract in forming [...] Read more.
An aqueous extract of Punica granatum peel was used as a biocatalyst for magnesium oxide nanoparticle (MgO-NP) synthesis, which was characterized via UV-Vis spectroscopy, TEM, EDX, FT-IR, XRD, DLS, and zeta potential. Data showed the efficacy of the plant aqueous extract in forming spherical, crystalline-nature, well-arranged MgO-NPs with sizes in the range of 10–45 nm with average sizes of 24.82 ± 8.85 nm. Moreover, EDX analysis revealed that the highest weight and atomic percentages were recorded for Mg and O ions. The green synthesized MgO-NPs showed antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, E. coli, Pseudomonas aeruginosa, and Candida albicans in a concentration-dependent manner with clear zones in the range of 8.7 ± 0.6 to 19.7 ± 0.5 mm with various concentrations. Also, the MIC value was varied to be 25 µg mL−1 for Gram-negative bacteria, B. subtilis, and C. albicans and 50 µg mL−1 for S. aureus. Moreover, MgO-NPs showed high activity against the 3rd-instar larvae of Culex quinquefasciatus. The mortality percentages were concentration- and time-dependent. Data analysis showed that the highest mortality was 88.3 ± 3.2%, attained at a concentration of 100 µg mL−1 after 72 h. Also, all originated pupae were malformed and did not hatch to adults, with mortality percentages of 100% at all concentrations. Overall, the P. granatum-mediated MgO-NPs showed promising activity in inhibiting the growth of pathogenic microbes and the hatching of C. quinquefasciatus larvae to adults. Full article
(This article belongs to the Special Issue Recent Advances in Antimicrobial Materials)
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9 pages, 2554 KiB  
Article
Silver Ions Incorporation into Nanofibers for Enhanced hMSC Viability
by Natalya A. Sitnikova, Anastasiya O. Solovieva, Elizaveta S. Permyakova, Alexander N. Sheveyko, Dmitry V. Shtansky and Anton M. Manakhov
Chemistry 2022, 4(3), 931-939; https://0-doi-org.brum.beds.ac.uk/10.3390/chemistry4030064 - 29 Aug 2022
Cited by 5 | Viewed by 1563
Abstract
Antimicrobial properties of silver have been known for a long time, but there is also cytotoxicity of high concentrations of silver. Therefore, it is important to select the concentration and shape of silver depending on the goals. The ideal wound dressing should ensure [...] Read more.
Antimicrobial properties of silver have been known for a long time, but there is also cytotoxicity of high concentrations of silver. Therefore, it is important to select the concentration and shape of silver depending on the goals. The ideal wound dressing should ensure that the wound remains optimally moist, protected from infections, has no toxic compounds, and stimulates regeneration. In the present work, we obtained a series of polycaprolactone-based nanomaterials fabricated by electrospinning and incorporated with silver ions (up to 0.6 at.%). By adjusting the magnetron current (0.3 A) and implanter voltage (5 kV), the deposition of TiO2 and Ag+ implantation into PCL/PEO nanofibers was optimized to achieve implantation of Ag+ without damaging the nanofibrous structure of the biodegradable nanofibers. The obtained results allow us to predict significant protection properties of the developed material not only from mechanical influence but also thanks to the antimicrobial effect due to silver ions, which is important for chronic wounds and injuries with a large area of damage and can activate host cells proliferation. Full article
(This article belongs to the Special Issue Recent Advances in Antimicrobial Materials)
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15 pages, 4204 KiB  
Article
Biogenic Silver Nanoparticles Conjugated with Nisin: Improving the Antimicrobial and Antibiofilm Properties of Nanomaterials
by Patricia Zimet, Ruby Valadez, Sofía Raffaelli, María Belén Estevez, Helena Pardo and Silvana Alborés
Chemistry 2021, 3(4), 1271-1285; https://0-doi-org.brum.beds.ac.uk/10.3390/chemistry3040092 - 04 Nov 2021
Cited by 13 | Viewed by 3053
Abstract
Microbial technology offers a green alternative for the synthesis of value-added nanomaterials. In particular, fungal compounds can improve silver nanoparticle production, stabilizing colloidal nanoparticles. Based on a previous study by our group, silver nanoparticles obtained using the extracellular cell-free extracts of Phanerochaete chrysosporium [...] Read more.
Microbial technology offers a green alternative for the synthesis of value-added nanomaterials. In particular, fungal compounds can improve silver nanoparticle production, stabilizing colloidal nanoparticles. Based on a previous study by our group, silver nanoparticles obtained using the extracellular cell-free extracts of Phanerochaete chrysosporium (PchNPs) have shown antimicrobial and antibiofilm activity against Gram-negative bacteria. Moreover, nisin—a bacteriocin widely used as a natural food preservative—has recently gained much attention due its antimicrobial action against Gram-positive bacteria in biomedical applications. Therefore, the aim of this work was to conjugate biogenic silver nanoparticles (PchNPs) with nisin to obtain nanoconjugates (PchNPs@nis) with enhanced antimicrobial properties. Characterization assays were conducted to determine physicochemical properties of PchNPs@nis, and also their antibacterial and antibiofilm activities were studied. The formation of PchNPs@nis was confirmed by UV-Vis, TEM, and Raman spectroscopy analysis. Different PchNPs@nis nanobioconjugates showed diameter values in the range of 60–130 nm by DLS and surface charge values between −20 and −13 mV. Nisin showed an excellent affinity to PchNPs, with binding efficiencies higher than 75%. Stable synthesized PchNPs@nis nanobioconjugates were not only able to inhibit biofilm formation by S. aureus, but also showed inhibition of the planktonic cell growth of Staphyloccocus aureus and Escherichia coli, broadening the spectrum of action of the unconjugated antimicrobials against Gram-positive and Gram-negative bacteria. In conclusion, these results show the promising application of PchNPs@nis, prepared via green technology, as potential antimicrobial nanomaterials. Full article
(This article belongs to the Special Issue Recent Advances in Antimicrobial Materials)
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15 pages, 2484 KiB  
Article
Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions
by Louise Gallagher, Alanna Smith, Kevin Kavanagh, Michael Devereux, John Colleran, Carmel Breslin, Karl G. Richards, Malachy McCann and A. Denise Rooney
Chemistry 2021, 3(2), 672-686; https://0-doi-org.brum.beds.ac.uk/10.3390/chemistry3020047 - 14 Jun 2021
Cited by 8 | Viewed by 3058
Abstract
Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)-octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin (BSA) was [...] Read more.
Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)-octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin (BSA) was condensed with glutaraldehyde (GLA) to form a BSA/GLA hydrogel. The corresponding Ag+-containing gels of all of the above hydrogels were also formed, and slow leaching of the biocidal transition metal ion from the gels bestowed broad spectrum antimicrobial activity. In the absence of added Ag+, CaALG/QA was the only material to deliver marginal to moderate antibacterial and antifungal effects. The Ag+ impregnated hydrogel systems have the potential to maintain the antimicrobial properties of silver, minimising the risk of toxicity, and act as reservoirs to afford ongoing sterility. Full article
(This article belongs to the Special Issue Recent Advances in Antimicrobial Materials)
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