Natural Products: Isolation, Identification and Biological Activity

A special issue of Chemistry (ISSN 2624-8549). This special issue belongs to the section "Biological and Natural Products".

Deadline for manuscript submissions: closed (15 June 2021) | Viewed by 2993

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Guest Editor
Department of Inorganic Chemistry, Medical University of Lublin, Lublin, Poland
Interests: liquid chromatography; optimization of chromatographic systems for separation of ionic compounds; quantitative analysis of ionic compounds in plant extracts; biological activity of plant extracts
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Special Issue Information

Dear Colleagues,

Dietary and herbal supplements are commonly used around the world, typically in an effort to maintain health, and prevent or treat illness. In many cases, these products are used concurrently with pharmaceutical therapies. Natural products are a rich source of compounds for drug development. One of the notable sources of natural products is medicinal plants. Natural products are a growing body of research for the development of new drugs derived for different eukaryotic and prokaryotic organisms.

However, there are still many species of plants that might possess a beneficial natural product that have still not been screened for medicinal use and might be a cause for a breakthrough in science. Therefore, more investigations should be done in various species of plants and other natural products. Currently, it is very crucial to develop effective and selective methods for the isolation of bioactive compounds from natural products, the identification of those compounds, and investigations on their biological activity.

Despite substantial developments in extraction and separation techniques, the isolation and identification of natural products from plants, marine organisms or microorganisms and investigations on their biological activity are still challenging tasks.

The papers include coverage of work on natural substances of the land and sea and of plants, microbes, and animals. Investigations on isolation, identification, structure elucidation and various biological activities are welcomed in this Special Issue.

We cordially invite researchers working in this field to contribute original research articles, short communications, and critical review articles. Short papers on one compound will also be welcome.

You may choose our Joint Special Issue in Molecules.

Prof. Dr. Anna Petruczynik
Guest Editor

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Keywords

  • Natural products
  • Isolation of active compounds from natural products
  • Analysis of natural products
  • Identification of natural products components
  • Biological activity of natural products

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Published Papers (1 paper)

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Research

7 pages, 1725 KiB  
Article
Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract
by Talkmore Ngarivhume, Anwar Noreljaleel, Susanna L. Bonnet and Anke Wilhelm
Chemistry 2021, 3(3), 854-860; https://0-doi-org.brum.beds.ac.uk/10.3390/chemistry3030062 - 12 Aug 2021
Cited by 4 | Viewed by 2496
Abstract
An antiplasmodial activity-guided isolation was carried out on the dichloromethane extract of Tithonia diversifolia dried leaves. A total of five germacranolide type sesquiterpene lactones and a new flavonol, 3,6-dihydroxy-2-(4′-hydroxyphenyl)-7-methoxy-4H-chromen-4-one, were isolated. The flavonol reported an IC50 above 6.00 µM against [...] Read more.
An antiplasmodial activity-guided isolation was carried out on the dichloromethane extract of Tithonia diversifolia dried leaves. A total of five germacranolide type sesquiterpene lactones and a new flavonol, 3,6-dihydroxy-2-(4′-hydroxyphenyl)-7-methoxy-4H-chromen-4-one, were isolated. The flavonol reported an IC50 above 6.00 µM against the chloroquine sensitive strain, NF54. The antimalarial activity of the Tithonia diversifolia dichloromethane leaf extract was attributed to orizabin and tagitinin C. Full article
(This article belongs to the Special Issue Natural Products: Isolation, Identification and Biological Activity)
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