Selected Papers from the International Electron Devices & Materials Symposium 2020 (IEDMS 2020)

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Electrochemical Devices and Sensors".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 17263

Special Issue Editors


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Guest Editor
Institute of Electro-Optical Engineering, Chang Gung University, Taoyuan 333, Taiwan
Interests: chemical sensors; gas sensor; solid-state electronics; VLSI process; 2D materials; LAPS
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Biomedical Engineering Research Center, Chang Gung University, Taoyuan 333, Taiwan
Interests: transistor-based sensors; metal oxides; 2D materials, nanowires; chemical sensors; gas sensors; bio sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

IEDMS 2020 is the 25th International Electron Devices & Materials Symposium sponsored by The Electronics Devices and Materials Association and Chang Gung University. This conference offers an annual platform for international scientists, engineers, and researchers to present the latest research results, ideas, developments, and applications in electron devices and materials. IEDMS 2020 will be hosted by Chang Gung University from 15 to 16 October, 2020 in Taoyuan, Taiwan. The themes of this conference cover fields for materials and devices including compound semiconductors, novel materials, nano and 2D materials, Si-based process, photonics, mixed-signal integrated circuits, AI chips, and sensors. Original high-quality papers related to these themes are welcomed, including theories, design, modeling, simulation, reliability, fabrication, integration, and applications in electronic relative fields. All accepted abstracts will be published in the conference proceedings. Selected papers will be recommended to related SCI journals for a Special Issue publication such as Chemosensors.

Prof. Dr. Chia-Ming Yang
Prof. Dr. Chao-Sung Lai
Guest Editors

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Keywords

  • Nanomaterial
  • Sensors
  • Device fabrication and applications
  • Semiconductor-based sensors
  • Metal-oxide-based sensors
  • Gas sensors
  • Microfluidics

Published Papers (6 papers)

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Research

11 pages, 3179 KiB  
Article
A Surface Acoustic Wave Sensor with a Microfluidic Channel for Detecting C-Reactive Protein
by Ming-Jer Jeng, Ying-Chang Li, Mukta Sharma, Chia-Wei Chen, Chia-Lung Tsai, Yen-Heng Lin, Shiang-Fu Huang, Liann-Be Chang and Chao-Sung Lai
Chemosensors 2021, 9(5), 106; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors9050106 - 10 May 2021
Cited by 8 | Viewed by 2793
Abstract
A surface acoustic wave (SAW) sensor with a microfluidic channel was studied to detect C-reactive protein (CRP). A piezoelectric lithium niobate substrate was used to examine the frequency response of the microfluidic SAW sensor. The amplitude (insertion loss) changes in the microfluidic SAW [...] Read more.
A surface acoustic wave (SAW) sensor with a microfluidic channel was studied to detect C-reactive protein (CRP). A piezoelectric lithium niobate substrate was used to examine the frequency response of the microfluidic SAW sensor. The amplitude (insertion loss) changes in the microfluidic SAW sensor were measured from the interaction of CRP/anti-CRP owing to mass variation. The fabricated microfluidic SAW sensor exhibited a detection limit of 4 ng/mL CRP concentration. A wide CRP concentration range (10 ng/mL to 0.1 mg/mL) can be detected by this sensor, which is higher than the existing CRP detection methods. A good linear relationship between the amplitude peak shift and CRP concentrations from 10 ng/mL to 0.1 mg/mL was obtained. The amplitude peak shifts in the sensor can be useful for estimating CRP concentration. This can be used as a biosensor to diagnose the risk of cardiovascular disease. Full article
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13 pages, 3550 KiB  
Article
Gold Nanoframe Array Electrode for Straightforward Detection of Hydrogen Peroxide
by Agnes Purwidyantri, Ya-Chung Tian, Gardin Muhammad Andika Saputra, Briliant Adhi Prabowo, Hui-Ling Liu, Chia-Ming Yang and Chao-Sung Lai
Chemosensors 2021, 9(2), 37; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors9020037 - 16 Feb 2021
Cited by 6 | Viewed by 3464
Abstract
The nanostructuring of a sensing membrane is performed through colloidal nanosphere lithography (NSL) techniques with a tiny polystyrene nanobead template 100 nm in size. The solvent ratio adjustment has been proven to be effective in assisting the monolayer deposition of small templating particles [...] Read more.
The nanostructuring of a sensing membrane is performed through colloidal nanosphere lithography (NSL) techniques with a tiny polystyrene nanobead template 100 nm in size. The solvent ratio adjustment has been proven to be effective in assisting the monolayer deposition of small templating particles with minimal defects. Two distinct structures, namely, a billowy gold nanostructure (BGN) where the nanobead template is left unetched and a gold nanoframe array (GNA) with a regular ring-like structure after template removal, are used for the extended-gate field-effect transistor (EGFET) electrodes. The GNA structure generates an electroactive surface area significantly (~20%) larger than its geometrical area as well as a greater surface roughness than the BGN. When integrated with the portable constant voltage–constant current (CVCC) FET circuitry for pH screening to determine the optimized measurement conditions for H2O2 sensing, the GNA sensing membrane also shows more improved Nernstian sensitivity at ~50 mV/pH than the BGN electrode. The more optimized sensitivity is then proven using the GNA in the detection of H2O2, the most common representative reactive oxygen species (ROS) involved in the environment, food, and neurodegenerative diseases, such as Parkinson´s and Alzheimer´s diseases. The GNA electrode has a sensitivity of 70.42 mV/log µM [H2O2] and a limit of detection (LoD) of 1.183 µM H2O2. The integrated ion sensing system employing unique, highly ordered gold array gate electrodes and a portable CVCC circuit system has shown a stable real-time output voltage signal, representing an alternative to bulky conventional FET devices for potential on-site H2O2 detection. Full article
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11 pages, 4320 KiB  
Article
AgNWs@TiO2 and AgNPs@TiO2 Double-Layer Photoanode Film Improving Light Capture and Application under Low Illumination
by Jung-Chuan Chou, Yu-Che Lin, Chih-Hsien Lai, Po-Yu Kuo, Yu-Hsun Nien, Ruei-Hong Syu, Zhen-Rong Yong and Yi-Ting Wu
Chemosensors 2021, 9(2), 36; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors9020036 - 11 Feb 2021
Cited by 5 | Viewed by 2163
Abstract
In this article, silver nanowires (AgNWs) were prepared and introduced into the double-layer photoanode of dye-sensitized solar cells (DSSCs). Silver nanowires with a diameter of about 50–60 nm and a length of 1–2 mm were prepared by the polyol method. The power conversion [...] Read more.
In this article, silver nanowires (AgNWs) were prepared and introduced into the double-layer photoanode of dye-sensitized solar cells (DSSCs). Silver nanowires with a diameter of about 50–60 nm and a length of 1–2 mm were prepared by the polyol method. The power conversion efficiency of the double-layer photoanode DSSC made of AgNWs@TiO2 and AgNPs@TiO2 composite materials is 6.38%. Compared with the unmodified DSSC, the composite double-layer photoanode combined with AgNWs and AgNPs increased the efficiency of DSSC by 58.7%. This increased efficiency was mainly due to the localized surface plasmon resonance effect caused by AgNPs and AgNWs. The increased light collection was caused by the plasma effect of AgNPs, and it increased the short-circuit photocurrent density (JSC). The conductive properties of AgNWs improved interface charge transfer and delay charge recombination. The effect of a low light environment on DSSC efficiency was also investigated, and the best photovoltaic conversion efficiency under an irradiance of 10 mW/cm2 was found to be 8.78%. Full article
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9 pages, 2259 KiB  
Communication
Silica Layer Used in Sensor Fabrication from a Low-Temperature Silane-Free Procedure
by Pei-Cheng Jiang, Yu-Ting Chow, Chi-Wei Chien, Cheng-Hsun-Tony Chang and Chii-Ruey Lin
Chemosensors 2021, 9(2), 32; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors9020032 - 04 Feb 2021
Cited by 2 | Viewed by 2373
Abstract
Silica (SiO2, silicon dioxide—a dielectric layer commonly used in electronic devices) is widely used in many types of sensors, such as gas, molecular, and biogenic polyamines. To form silica films, core shell or an encapsulated layer, silane has been used as a [...] Read more.
Silica (SiO2, silicon dioxide—a dielectric layer commonly used in electronic devices) is widely used in many types of sensors, such as gas, molecular, and biogenic polyamines. To form silica films, core shell or an encapsulated layer, silane has been used as a precursor in recent decades. However, there are many hazards caused by using silane, such as its being extremely flammable, the explosive air, and skin and eye pain. To avoid these hazards, it is necessary to spend many resources on industrial safety design. Thus, the silica synthesized without silane gas which can be determined as a silane-free procedure presents a clean and safe solution to manufactures. In this report, we used the radio frequency (rf = 13.56 MHz) plasma-enhanced chemical vapor deposition technique (PECVD) to form a silica layer at room temperature. The silica layer is formed in hydrogen-based plasma at room temperature and silane gas is not used in this process. The substrate temperature dominates the silica formation, but the distance between the substrate and electrode (DSTE) and the methane additive can enhance the formation of a silica layer on the Si wafer. This silane-free procedure, at room temperature, is not only safer and friendlier to the environment but is also useful in the fabrication of many types of sensors. Full article
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13 pages, 3092 KiB  
Article
Fabrication of Zinc Protoporphyrin-Modified Gold Electrode for Sensitive and Fast Detection of Vascular Endothelial Growth Factor
by Hung-Yu Lin, Chin-Cheng Liao and Mu-Yi Hua
Chemosensors 2021, 9(2), 21; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors9020021 - 23 Jan 2021
Cited by 3 | Viewed by 2996
Abstract
Vascular endothelial growth factor (VEGF) is directly related to cancer growth and its distant spread, and thus, it is considered a promising biomarker for diagnosis and post-treatment monitoring of patients with malignancies. Zinc protoporphyrin (ZnPP) is a zinc-centered raw purple compound (protoporphyrin) that [...] Read more.
Vascular endothelial growth factor (VEGF) is directly related to cancer growth and its distant spread, and thus, it is considered a promising biomarker for diagnosis and post-treatment monitoring of patients with malignancies. Zinc protoporphyrin (ZnPP) is a zinc-centered raw purple compound (protoporphyrin) that has unique optical and electrochemical characteristics. In this study, we used a ZnPP-modified gold electrode to generate a chemical bond with Avastin by self-assembly and fabricate a Au/ZnPP/Avastin electrode. Bovine serum protein (BSA) was added to the electrode to prevent non-specific linkage with biomolecules. The prepared Au/ZnPP/Avastin/BSA electrodes were used for the detection of VEGF by cyclic voltammetry and amperometry. The optical properties of ZnPP were analyzed with an ultraviolet/visible/near-infrared spectrometer and a photoluminescence spectrometer. The structural and hydrophilic/hydrophobic properties of the ZnPP-modified gold electrodes were investigated by Fourier-transform infrared spectroscopy and contact angle gauge, respectively. VEGF was detected with the Au/ZnPP/Avastin/BSA electrodes prepared either with (w/LT) or without light treatment (w/o LT). The w/LT electrode showed a linear range and a sensitivity of 0.1 pg/mL–10 ng/mL and 6.52 μA/log(pg/mL)-cm2, respectively; the corresponding values for the w/o LT electrode were 10 pg/mL–10 ng/mL and 3.15 μA/log(pg/mL)-cm2, respectively. The w/LT electrode had good specificity for VEGF and was minimally influenced by other molecules. The excellent detection range, high sensitivity, and high selectivity for VEGF detection indicate that Au/ZnPP/Avastin electrodes have great potential for diagnostic and prognostic applications in patients with malignancies. Full article
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12 pages, 2377 KiB  
Article
Preparation and Characterization of Au/NiPc/Anti-p53/BSA Electrode for Application as a p53 Antigen Sensor
by Yen-Jou Chen, Yu-Ren Peng, Hung-Yu Lin, Tsung-Yu Hsueh, Chao-Sung Lai and Mu-Yi Hua
Chemosensors 2021, 9(1), 17; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors9010017 - 19 Jan 2021
Cited by 5 | Viewed by 2643
Abstract
While the tumor suppressor protein p53 regulates the cell cycle to prevent cell damage, it also triggers apoptosis and prevents cancer. These inhibitory functions may disappear once the p53 gene is mutated. Under these circumstances, the detection of p53 protein concentrations can have [...] Read more.
While the tumor suppressor protein p53 regulates the cell cycle to prevent cell damage, it also triggers apoptosis and prevents cancer. These inhibitory functions may disappear once the p53 gene is mutated. Under these circumstances, the detection of p53 protein concentrations can have significant clinical applications. In this study, nickel phthalocyanine (NiPc) was coated on a gold electrode to produce a modified Au/NiPc electrode. p53 antibodies were bonded to the Au/NiPc electrode by the Ni+2 ion in NiPc, which can be self-assembled with the imidazole group of the p53 protein. The Au/NiPc/anti-p53 electrode was subsequently dripped with a buffer solution of bovine serum albumin (BSA) to form the Au/NiPc/anti-p53/BSA electrode, which was used for the detection of p53 antigen under 10 mM potassium ferricyanide/potassium ferrocyanide (K3Fe(CN)6/K4Fe(CN)6) solution by cyclic voltammetry and differential pulse voltammetry analyses. The linear detection range and the sensitivity for the p53 antigen were 0.1–500 pg/mL and 60.65 μA/Log (pg/mL)-cm2, respectively, with a detection time of 90–150 s. In addition, Au/NiPc/anti-p53 (100 ng/mL)/BSA electrodes were tested for specificity using glucose, bovine serum albumin, histidine, ascorbic acid, uric acid, prostate-specific antigen, human serum albumin, and human immunoglobulin G. All p-values were <0.0005, indicating an outstanding specificity. Full article
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