Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.9
4.2
Journals
Chemosensors
Special Issues
Advanced Sensing Technologies in Medical and Pharmaceutical Analysis
share announcement

Advanced Sensing Technologies in Medical and Pharmaceutical Analysis

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Analytical Methods, Instrumentation and Miniaturization".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 4467

Special Issue Editor

Prof. Dr. María Ramos-Payan

E-Mail Website
Guest Editor
Department of Analytical Chemistry, Faculty of Chemistry, Universidad de Sevilla, 41012 Seville, Spain
Interests: microfluidics; microchips; sample treatment; point of care; miniaturization; portable devices; optical detection; biological and environmental samples
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

New portable systems that allow the detection and quantification of different compounds have emerged as a prominent trend in recent years. There are more and more devices that integrate sensors and that allow the analysis of different types of compounds, although it is true that their use in the pharmaceutical field is more limited. The quantification of compounds in biological or environmental samples requires low detection limits in most cases. For this reason, it is common for this type of analysis to be carried out in analysis laboratories with advanced instrumental techniques, such as a mass spectrometer, liquid or gas chromatography. However, these tests are generally expensive. Compared to laboratory-scale instruments, advanced detection technologies are extremely attractive due to the advantages of low cost, time savings, ease of use, simplified sample pretreatment, high sensitivity, and excellent selectivity.

This Special Issue aims to present readers with the hottest topics in chemosensor applications. The issue invites contributions related but not limited to novel concepts of wearable chemosensors, new devices, and potential applications with emphasis on optical sensors, electrochemical sensors, and biosensors:

  • Pharmaceutical applications for pollutants and other compounds;
  • Enabling technologies of wearable chemosensors;
  • Optical detection into miniaturized and portable systems;
  • New materials for bio-integrated wearable chemosensors;
  • Biosensor and biomedical applications.

Prof. Dr. María Ramos-Payan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • automation
  • miniaturization
  • applications
  • optical sensor
  • electrochemical sensor
  • biosensor
  • pharmaceutical analysis

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

11 pages, 2029 KiB  
Article
α-Glucosidase-Mediated Glucometer Readout for Portable Monitoring of Acarbose and Migliol
by Hao Zhang and Feng-Qing Yang
Chemosensors 2022, 10(6), 198; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors10060198 - 24 May 2022
Viewed by 1941
Abstract
The α-glucosidase inhibitor is regarded as one of the most important drugs for the treatment of diabetes, which can control postprandial blood glucose levels via prolonging the carbohydrate digestion time and retarding the carbohydrates’ absorption. The present work aims to establish a facile [...] Read more.
The α-glucosidase inhibitor is regarded as one of the most important drugs for the treatment of diabetes, which can control postprandial blood glucose levels via prolonging the carbohydrate digestion time and retarding the carbohydrates’ absorption. The present work aims to establish a facile bioanalytical method, based on α-glucosidase catalyzing the hydrolysis of 2-O-alpha-D-Glucopyranosyl-L-ascorbic acid (AA-2G), for the quantification of acarbose and migliol using a personal glucose meter (PGM). The hydrolysis products (ascorbic acid and glucose) can trigger the reduction of K3[Fe(CN)6] to K4[Fe(CN)6] in the glucose test strips, which results in the formation of the electron, which can be measured by PGM. Thus, ascorbic acid and glucose can be simultaneously measured by a simplified and miniaturized PGM method. However, the products produced by the hydrolysis of AA-2G will be decreased after the addition of acarbose or migliol to inhibit the activity of α-glucosidase, thereby resulting in a decreased PGM readout. After being incubated with α-glucosidase for 3.0 min and enzymatic reaction for 5.0 min, the quantitative detection of acarbose and migliol can be achieved within the ranges of 1.0–30.0 μM with the limit of detection of 0.33 μM and 3.0–33.3 μM with the limit of detection of 1.0 μM, respectively. IC50 values for acarbose and migliol are calculated to be 10.0 μM and 16.0 μM, respectively. The recoveries of the acarbose and migliol spiked with three different concentrations (final concentrations of 10.0, 20.0, and 30.0 μM) in human serum sample are in the ranges of 89.6–114.5% and 93.9–106.5%, respectively. These results demonstrate that the developed PGM method may be useful in future studies on therapeutic monitoring of acarbose and migliol. Full article
(This article belongs to the Special Issue Advanced Sensing Technologies in Medical and Pharmaceutical Analysis)
►▼ Show Figures

Figure 1

14 pages, 2291 KiB  
Article
Development of a Coelenterazine Derivative with Enhanced Superoxide Anion-Triggered Chemiluminescence in Aqueous Solution
by José Pedro Silva, Patricia González-Berdullas, Joaquim C. G. Esteves da Silva and Luís Pinto da Silva
Chemosensors 2022, 10(5), 174; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors10050174 - 05 May 2022
Cited by 7 | Viewed by 2093
Abstract
Superoxide anion is a reactive oxygen species (ROS) of biological interest. More specifically, it plays a role in intra- and intercellular signaling, besides being associated with conditions such as inflammation and cancer. Given this, efforts have been made by the research community to [...] Read more.
Superoxide anion is a reactive oxygen species (ROS) of biological interest. More specifically, it plays a role in intra- and intercellular signaling, besides being associated with conditions such as inflammation and cancer. Given this, efforts have been made by the research community to devise new sensing strategies for this ROS species. Among them, the chemiluminescent reaction of marine Coelenterazine has been employed as a sensitive and dynamic probing approach. Nevertheless, chemiluminescent reactions are typically associated with lower emissions in aqueous solutions. Herein, here we report the synthesis of a new Coelenterazine derivative with the potential for superoxide anion sensing. Namely, this novel compound is capable of chemiluminescence in a dose-dependent manner when triggered by this ROS species. More importantly, the light-emission intensities provided by this derivative were relevantly enhanced (intensities 2.13 × 101 to 1.11 × 104 times higher) in aqueous solutions at different pH conditions when compared to native Coelenterazine. The half-life of the chemiluminescent signal is also greatly increased for the derivative. Thus, a new chemiluminescence molecule with significant potential for superoxide anion sensing was discovered and reported for the first time. Full article
(This article belongs to the Special Issue Advanced Sensing Technologies in Medical and Pharmaceutical Analysis)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop